Isa Yasuka, Miyakawa Yuri, Yanagisawa Masayoshi, Goto Tsuyoshi, Kang Min-Sook, Kawada Teruo, Morimitsu Yasujiro, Kubota Kikue, Tsuda Takanori
College of Bioscience and Biotechnology, Chubu University, Kasugai, 1200 Matsumoto-cho, Kasugai, Aichi 487-8501, Japan.
Biochem Biophys Res Commun. 2008 Aug 29;373(3):429-34. doi: 10.1016/j.bbrc.2008.06.046. Epub 2008 Jun 23.
In this study, we demonstrated that the two ginger-derived components have a potent and unique pharmacological function in 3T3-L1 adipocytes via different mechanisms. Both pretreatment of 6-shogaol (6S) and 6-gingerol (6G) significantly inhibited the tumor necrosis factor-alpha (TNF-alpha) mediated downregulation of the adiponectin expression in 3T3-L1 adipocytes. Our study demonstrate that (1) 6S functions as a PPARgamma agonist with its inhibitory mechanism due to the PPARgamma transactivation, and (2) 6G is not a PPARgamma agonist, but it is an effective inhibitor of TNF-alpha induced c-Jun-NH(2)-terminal kinase signaling activation and thus, its inhibitory mechanism is due to this inhibitory effect.
在本研究中，我们证明了两种源自姜的成分通过不同机制在3T3-L1脂肪细胞中具有强大且独特的药理功能。6-姜辣素（6S）和6-姜酚（6G）的预处理均显著抑制肿瘤坏死因子-α（TNF-α）介导的3T3-L1脂肪细胞中脂联素表达的下调。我们的研究表明：（1）6S作为一种PPARγ激动剂，其抑制机制归因于PPARγ反式激活；（2）6G不是PPARγ激动剂，但它是TNF-α诱导的c-Jun-NH₂-末端激酶信号激活的有效抑制剂，因此，其抑制机制归因于这种抑制作用。
