Lee Young Joo, Ryu Heui-Young, Kim Hyun-Kyung, Min Chung Sik, Lee Jin Hee, Kim Eunhee, Nam Bong Hyun, Park Joo Hong, Jung Jin Young, Jang Dong Deuk, Park Eun Young, Lee Kwan-Hee, Ma Jin-Young, Won Hey-Sung, Im Moon-Whan, Leem Jong-Han, Hong Yun-Chul, Yoon Hae-Seong
Human Exposure Assessment Team, National Institute of Toxicological Research, Korea Food and Drug Administration, Seoul, Republic of Korea.
Reprod Toxicol. 2008 Aug;25(4):413-9. doi: 10.1016/j.reprotox.2008.05.058. Epub 2008 May 25.
Bisphenol A (BPA) is a well-known endocrine disrupter used widely. Despite the potential risk of human exposure to BPA, little information exists concerning maternal and fetal exposure to BPA during pregnancy in Korea. This study purposed to evaluate the correlation between maternal and fetal exposure, and to determine exposure levels to BPA in Korean pregnant women and their fetuses. Maternal blood and umbilical cord blood were collected from 300 subjects, and total BPA levels were measured. Blood BPA concentrations ranged from non-detectable to 66.48 microg/L in pregnant women and from non-detectable to 8.86 microg/L in umbilical cords. Serum BPA levels in most pregnant women were higher than in corresponding fetal umbilical cords and a positive correlation was found between in maternal and fetal BPA concentrations (p<0.05).
双酚A（BPA）是一种广泛使用的著名内分泌干扰物。尽管人类接触双酚A存在潜在风险，但在韩国，关于孕期母婴接触双酚A的信息却很少。本研究旨在评估母婴接触之间的相关性，并确定韩国孕妇及其胎儿体内双酚A的接触水平。从300名受试者中采集了母体血液和脐带血，并测量了双酚A的总水平。孕妇血液中双酚A浓度范围为未检出至66.48微克/升，脐带血中为未检出至8.86微克/升。大多数孕妇血清双酚A水平高于相应胎儿的脐带血，且母体和胎儿双酚A浓度之间存在正相关（p<0.05）。
