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[儿童亲属肾同种异体移植]

[Cognated kidney allotransplantation in children].

作者信息

Goriaĭnov V A, Kaabak M M, Babenko N N, Zokoev A K, Morozova M M, Shishlov L A

出版信息

Khirurgiia (Mosk). 2008(6):58-62.

Abstract

47 children at the age from 7 months till 16 years in terminal stage of chronic renal failure underwent related kidney allotransplantation. Kidney donors were mother (25), father (10), grandmother (4), uncle (3), brother (3), cousin (1), grandfather (1). On purpose of evaluation of pretransplantation hemodialysis duration the patients were divided into 2 groups: 1) duration of dialysis 0-12 months, 2) duration of dialysis more than 12 months. Such characteristics as actuarial probability of survival, growth and weight dynamics in children were evaluated. The comparative analysis show that the weight and growth rate is higher in children from the first group. Five-year actuarial probability of survival was 94% in the first group and 85% in the second group (p<0.01). Thus the research results show that relative kidney transplantation is the optimum treatment mode for the children in terminal stage of chronic renal failure, contributes to treatment results improvement and reduction of pretransplantation hemodialysis duration.

摘要

47名年龄在7个月至16岁的慢性肾衰竭终末期儿童接受了亲属肾同种异体移植。肾脏供体为母亲(25例)、父亲(10例)、祖母(4例)、叔叔(3例)、兄弟(3例)、堂兄弟(1例)、祖父(1例)。为了评估移植前血液透析的持续时间,将患者分为2组:1)透析持续时间0 - 12个月,2)透析持续时间超过12个月。评估了儿童的生存精算概率、生长和体重动态等特征。比较分析表明,第一组儿童的体重和生长速度更高。第一组的5年生存精算概率为94%,第二组为85%(p<0.01)。因此,研究结果表明,亲属肾移植是慢性肾衰竭终末期儿童的最佳治疗方式,有助于改善治疗效果并缩短移植前血液透析的持续时间。

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