Welsch Michael A, Dobrosielski Devon A, Arce-Esquivel Arturo A, Wood Robert H, Ravussin Eric, Rowley Christina, Jazwinski S Michal
Louisiana State University, Baton Rouge, LA, USA.
Med Sci Sports Exerc. 2008 Jul;40(7):1237-43. doi: 10.1249/MSS.0b013e31816c5552.
The probability that an individual is able to live independently decreases sharply below the threshold score of 57 units on the physical functional performance (PFP-10) test.
To examine the relation between brachial artery flow-mediated dilation (BAFMD) on individual and total scores on the PFP-10. We hypothesized that lower scores on the PFP-10 test would be associated with lower BAFMD.
Sixty-four men (age, 84 +/- 11 yr) from the Louisiana Healthy Aging Study were studied. Participants were classified by their performance on the PFP-10 test (Class I, score <26; Class II, score between 26 and 57; and Class III, score > 57). BAFMD was assessed after 5 min of forearm occlusion, using high-resolution ultrasonography.
The average total score on the PFP-10 test and BAFMD were 42.9 +/- 22 U and 2.76 +/- 2.13%, respectively. The BAFMD was associated with total PFP-10 score (r = 0.45, P = 0.0001) and age (r = -0.36, P = 0.003). BAFMD was significantly different (P = 0.001) between the PFP-10 classes (Class I, 1.44% [95% CI, 0.49-2.39]; Class II, 2.67% [95% CI, 1.95-3.38]; and Class III, 4.01% [95% CI, 3.16-4.85]).
This study reports significant relationships between BAFMD and individual and combined measures of physical function in elderly men. More specifically, when individuals were categorized based on their PFP-10 total score, those in the highest functional class, exhibited the highest BAFMD, compared to those in the middle class, who had greater vasoreactivity than those in the lowest functional class.
个体能够独立生活的概率在身体功能表现（PFP - 10）测试得分低于57分的阈值时会急剧下降。
研究个体肱动脉血流介导的扩张（BAFMD）与PFP - 10总分之间的关系。我们假设PFP - 10测试得分较低与较低的BAFMD相关。
对来自路易斯安那健康老龄化研究的64名男性（年龄，84±11岁）进行了研究。参与者根据他们在PFP - 10测试中的表现进行分类（I类，得分<26；II类，得分在26至57之间；III类，得分>57）。在前臂阻断5分钟后，使用高分辨率超声评估BAFMD。
PFP - 10测试的平均总分和BAFMD分别为42.9±22 U和2.76±2.13%。BAFMD与PFP - 10总分（r = 0.45，P = 0.0001）和年龄（r = -0.36，P = 0.003）相关。PFP - 10各分类之间的BAFMD有显著差异（P = 0.001）（I类，1.44%[95%CI，0.49 - 2.39]；II类，2.67%[95%CI，1.95 - 3.38]；III类，4.01%[95%CI，3.16 - 4.85]）。
本研究报告了老年男性中BAFMD与个体身体功能及综合测量指标之间的显著关系。更具体地说，当根据PFP - 10总分对个体进行分类时，功能最高等级的个体表现出最高的BAFMD，与中等等级个体相比，中等等级个体的血管反应性高于功能最低等级的个体。
