Santos-Parker Jessica R, Lubieniecki Kara L, Rossman Matthew J, Van Ark Hannah J, Bassett Candace J, Strahler Talia R, Chonchol Michel B, Justice Jamie N, Seals Douglas R
Integrative Physiology, University of Colorado Boulder, Boulder, CO, USA.
Medicine (Renal Diseases and Hypertension), University of Colorado Denver, Aurora, CO, USA.
Nutr Healthy Aging. 2018 Jun 15;4(4):323-333. doi: 10.3233/NHA-170029.
Recent studies suggest curcumin is a promising nutraceutical for improving important clinical and physiological markers of healthy aging, including motor and cognitive function.
To determine if curcumin supplementation improves motor and cognitive function in healthy middle-aged and older adults.
39 healthy men and postmenopausal women (45-74 yrs) were randomized to 12 weeks of placebo ( = 19) or curcumin supplementation (2000 mg/day Longvida; = 20) with motor and cognitive function assessed at week 0 and 12.
Using measures of the NIH Toolbox and other standardized tests, there were no changes in muscle strength and rate of torque development, dexterity, fatigability, mobility, endurance, and balance between the placebo and curcumin groups after 12 weeks (all > 0.05). Additionally, there were no changes after 12 weeks of placebo and curcumin supplementation in measures of fluid cognitive ability, a cognitive domain that declines with age, including processing speed, executive function, working memory, and episodic memory (all > 0.3). There were marginal changes in language, a measure of crystallized cognitive ability that is stable with age, following the intervention, wherein reading decoding increased 3% in the curcumin group (post: 2428±35 vs. pre: 2357±34, = 0.003), but was unchanged in the placebo group (post: 2334±39 vs. pre: 2364±40, = 0.07).
Overall, 12 weeks of curcumin supplementation does not improve motor and cognitive functions in healthy middle-aged and older adults. It is possible that curcumin may enhance these functions in groups with greater baseline impairments than those studied here, including adults greater than 75 years of age and/or patients with clinical disorders.
近期研究表明，姜黄素是一种很有前景的营养保健品，可改善健康老龄化的重要临床和生理指标，包括运动和认知功能。
确定补充姜黄素是否能改善健康中年和老年人的运动和认知功能。
39名健康男性和绝经后女性（45 - 74岁）被随机分为两组，一组服用安慰剂12周（n = 19），另一组补充姜黄素（Longvida 2000毫克/天；n = 20），并在第0周和第12周评估运动和认知功能。
使用美国国立卫生研究院工具箱（NIH Toolbox）的测量方法和其他标准化测试，12周后，安慰剂组和姜黄素组在肌肉力量、扭矩发展速率、灵活性、易疲劳性、活动能力、耐力和平衡方面均无变化（所有P>0.05）。此外，在补充安慰剂和姜黄素12周后，随着年龄下降的流体认知能力指标，包括处理速度、执行功能、工作记忆和情景记忆，均无变化（所有P>0.3）。干预后，作为一种随年龄稳定的晶体认知能力指标的语言能力有轻微变化，其中姜黄素组的阅读解码能力提高了3%（干预后：2428±35 vs. 干预前：2357±34，P = 0.003），而安慰剂组无变化（干预后：2334±39 vs. 干预前：2364±40，P = 0.07）。
总体而言，补充姜黄素12周并不能改善健康中年和老年人的运动和认知功能。姜黄素可能在基线损伤比本研究对象更大的人群中增强这些功能，包括75岁以上的成年人和/或患有临床疾病的患者。
