Bloch Yuval, Grisaru Nimrod, Harel Eiran V, Beitler Gabriela, Faivel Nurit, Ratzoni Gideon, Stein Daniel, Levkovitz Yechiel
Shalvata Mental Health Center, Hod Hasharon, Israel.
J ECT. 2008 Jun;24(2):156-9. doi: 10.1097/YCT.0b013e318156aa49.
This open-label pilot study examined repetitive transcranial magnetic stimulation as a possible treatment of adolescent resistant depression.
Nine adolescents (aged 16-18 years) with severe resistant depression (determined by SCID) were recruited, and their depression, suicidality, and cognitive functions were evaluated before, during, and after a course of twenty 10-Hz, 2-second trains (intertrain intervals of 58 seconds) given over 20 min/d over 14 working days.
Lower levels of depression with progression in therapy were recorded by both the Beck Depression Inventory and Child Depression Rating Scale measures (F1.7,14.01 = 4.52, P < 0.05; F4,32 = 6.645, P < 0.01, respectively). Three patients reached the primary outcome measure of less than 30% reduction in their Child Depression Rating Scale. The effect on suicidality was not significant. Side effects were considered mild.
Repetitive transcranial magnetic stimulation might be a possible therapy for adolescent depression. Our preliminary findings warrant double-blind, controlled studies.
本开放性试点研究探讨重复经颅磁刺激作为青少年难治性抑郁症一种可能治疗方法的效果。
招募了9名（年龄在16 - 18岁之间）患有严重难治性抑郁症（由SCID确定）的青少年，在14个工作日内，每天20分钟给予20次10赫兹、每次2秒的刺激序列（序列间间隔58秒），分别在治疗前、治疗期间和治疗后评估他们的抑郁、自杀倾向和认知功能。
贝克抑郁量表和儿童抑郁评定量表测量均显示，随着治疗进展抑郁水平降低（分别为F1.7,14.01 = 4.52，P < 0.05；F4,32 = 6.645，P < 0.01）。3名患者达到了儿童抑郁评定量表降低幅度小于30%的主要结局指标。对自杀倾向的影响不显著。副作用被认为较轻。
重复经颅磁刺激可能是青少年抑郁症的一种治疗方法。我们的初步研究结果需要进行双盲对照研究。
