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通过mRNA结合蛋白的亚细胞重新定位对基因表达进行转录后调控。

Post-transcriptional control of gene expression through subcellular relocalization of mRNA binding proteins.

作者信息

Cammas Anne, Lewis Stephen M, Vagner Stephan, Holcik Martin

机构信息

INSERM U563, Toulouse F-31000, France.

出版信息

Biochem Pharmacol. 2008 Dec 1;76(11):1395-403. doi: 10.1016/j.bcp.2008.05.022. Epub 2008 Jul 9.

DOI:10.1016/j.bcp.2008.05.022
PMID:18582437
Abstract

Eukaryotic cells have developed multiple mechanisms to respond to different physiological cues, such as cellular stress, which allow the cells to adapt themselves to their new environment. The regulation of post-transcriptional gene expression is an important component of the cellular stress response and is mediated by mRNA binding proteins (mRBPs). Recently, several studies have shown that regulated subcellular localization of mRBPs upon diverse stimuli (such as cellular stress) provides an additional level of regulation for gene expression.

摘要

真核细胞已发展出多种机制来响应不同的生理信号，如细胞应激，使细胞能够适应新环境。转录后基因表达的调控是细胞应激反应的重要组成部分，由mRNA结合蛋白（mRBPs）介导。最近，多项研究表明，在多种刺激（如细胞应激）下，mRBPs的亚细胞定位受到调控，为基因表达提供了额外的调控水平。

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