Schwartz Martin A, DeSimone Douglas W
Department of Microbiology and Biomedical Engineering, Cardiovascular Research Center and Mellon Urological Cancer Research Institute, University of Virginia Charlottesville, VA 22908, USA.
Curr Opin Cell Biol. 2008 Oct;20(5):551-6. doi: 10.1016/j.ceb.2008.05.005. Epub 2008 Jun 24.
Integrins and cadherins are tri-functional: they bind ligands on other cells or in the extracellular matrix, connect to the cytoskeleton inside the cell, and regulate intracellular signaling pathways. These adhesion receptors therefore transmit mechanical stresses and are well positioned to mediate mechanotransduction. Studies of cultured cells have shown that both integrin- and cadherin-mediated adhesion are intrinsically mechanosensitive. Strengthening of adhesions in response to mechanical stimulation may be a central mechanism for mechanotransduction. Studies of developing organisms suggest that these mechanisms contribute to tissue level responses to tension and compression, thereby linking morphogenetic movements to cell fate decisions.
它们可与其他细胞上或细胞外基质中的配体结合，连接细胞内部的细胞骨架，并调节细胞内信号通路。因此，这些黏附受体可传递机械应力，并在介导机械转导方面具有良好的定位。对培养细胞的研究表明，整合素介导和钙黏着蛋白介导的黏附本质上都是机械敏感的。响应机械刺激而增强黏附可能是机械转导的核心机制。对发育中的生物体的研究表明，这些机制有助于组织水平对张力和压缩的反应，从而将形态发生运动与细胞命运决定联系起来。
