Narbutt Joanna, Lukamowicz Jolanta, Bogaczewicz Jarosław, Sysa-Jedrzejowska Anna, Torzecka Jolanta Dorota, Lesiak Aleksandra
Department of Dermatology, Medical University of Lodz, 94-017 Lodz, Poland.
Mediators Inflamm. 2008;2008:875394. doi: 10.1155/2008/875394.
As most studies on pemphigus vulgaris (PV) pathogenesis concern its active stage, we aimed to evaluate the serum concentration of TNF-alpha, IL-1, and IL-6 in PV patients in clinical remission. The study group consisted of sera from 19 PV patients in active stage and from 24 patients in clinical remission. 19 sera taken from healthy subjects served as the controls. Serum IL-6 concentrations in PV active and PV remission group were significantly higher when compared to the controls (P < .05). In patients in active stage of PV, a significant correlation between serum IL-1 and IL-6 concentrations was found (r(P) = 0.46; P < .05). We also found a negative correlation between TNF-alpha level and pemphigus antibodies titer in the patients from the remission group (r(S) = -0.47303; P < .02). Our data suggest that IL-6 and TNF-alpha may be involved in maintaining immunological disturbances in remission stage of PV.
由于大多数关于寻常型天疱疮（PV）发病机制的研究都关注其活动期，我们旨在评估临床缓解期PV患者血清中肿瘤坏死因子-α（TNF-α）、白细胞介素-1（IL-1）和白细胞介素-6（IL-6）的浓度。研究组包括19例活动期PV患者和24例临床缓解期患者的血清。取自健康受试者的19份血清作为对照。与对照组相比，PV活动组和PV缓解组的血清IL-6浓度显著更高（P < 0.05）。在PV活动期患者中，发现血清IL-1和IL-6浓度之间存在显著相关性（r(P) = 0.46；P < 0.05）。我们还发现缓解组患者的TNF-α水平与天疱疮抗体滴度之间存在负相关（r(S) = -0.47303；P < 0.02）。我们的数据表明，IL-6和TNF-α可能参与维持PV缓解期的免疫紊乱。
