Gholibeigian Zeinab, Izad Maryam, Daneshpazhooh Maryam, Mortazavi Hossein, Salehi Zahra, Behruzifar Shirin, Akhdar Marwa, Tavakolpour Soheil, Azizpour Arghavan
Autoimmune Bullous Disease Research Center, Department of Dermatology, Razi Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Dermatol Ther. 2020 Nov;33(6):e14071. doi: 10.1111/dth.14071. Epub 2020 Sep 6.
The exact pathogenesis of Pemphigus Vulgaris (PV) has remained unclear, but it seems that cytokines play critical roles in this disease. This study aims to assess the serum levels of interleukin (IL)-6, IL-17, IL-23, and TGF-β in PV patients and compare the results to the healthy controls. Serum levels of IL6, IL-17, IL-23, and TGF-β were successfully determined by enzyme-linked immunosorbent assay (ELISA) in 27 newly diagnosed PV, 32 patients in remission, and 29 healthy controls. It was shown that the mean serum levels of IL-17, IL-23, and TGF-β serum are significantly different among the PV patients and healthy controls (P values: <.001, .001, and .003, respectively). It was found that new PV patients have lower serum levels of IL-17, IL-23, and TGF-β as compared to healthy controls (P values: <.001, <.001, and .003, respectively). Regarding IL-6, no significant difference was observed between the healthy controls and the other two groups of patients. IL-17, IL-23, and TGF-β are involved in the pathogenesis of PV. However, more studies are required to clarify their exact roles in the immunopathogenesis of PV.
寻常型天疱疮（PV）的确切发病机制尚不清楚，但细胞因子似乎在该疾病中起关键作用。本研究旨在评估PV患者血清中白细胞介素（IL）-6、IL-17、IL-23和转化生长因子-β（TGF-β）的水平，并将结果与健康对照进行比较。通过酶联免疫吸附测定（ELISA）成功测定了27例新诊断的PV患者、32例缓解期患者和29例健康对照血清中IL-6、IL-17、IL-23和TGF-β的水平。结果显示，PV患者与健康对照之间IL-17、IL-23和TGF-β血清的平均水平存在显著差异（P值分别为<0.001、0.001和0.003）。发现新诊断的PV患者与健康对照相比，血清中IL-17、IL-23和TGF-β水平较低（P值分别为<0.001、<0.001和0.003）。关于IL-6，健康对照与其他两组患者之间未观察到显著差异。IL-1,7、IL-23和TGF-β参与了PV的发病机制。然而，需要更多研究来阐明它们在PV免疫发病机制中的确切作用。
