LUSH准备在嗅觉领域扮演主角。

LUSH shapes up for a starring role in olfaction.

作者信息

Stowers Lisa, Logan Darren W

机构信息

Department of Cell Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

出版信息

Cell. 2008 Jun 27;133(7):1137-9. doi: 10.1016/j.cell.2008.06.010.

DOI:10.1016/j.cell.2008.06.010

PMID:18585346

Abstract

In the fruit fly Drosophila, odorant-binding proteins are secreted into the fluid that bathes olfactory neurons. Laughlin et al. (2008) now challenge the assumption that the odorant-binding protein LUSH passively transports its pheromone to a specific olfactory receptor. Instead, LUSH undergoes a conformational change upon pheromone binding that is sufficient for neuronal activation.

摘要

在果蝇中，气味结合蛋白被分泌到包围嗅觉神经元的液体中。劳克林等人（2008年）现在对气味结合蛋白LUSH被动地将其信息素转运至特定嗅觉受体这一假设提出了质疑。相反，LUSH在结合信息素后会发生构象变化，这种变化足以激活神经元。