Pu Chang En, Linacre Adrian
Scientific and Technical Research Center, Ministry Justice Investigation Bureau, Taipei County 231, Taiwan, ROC.
J Forensic Leg Med. 2008 Aug;15(6):373-7. doi: 10.1016/j.jflm.2008.02.004. Epub 2008 Apr 11.
A half-sibship relationship is when two siblings share only one parent. It may be necessary to determine if two individuals are half-siblings in cases of immigration, inheritance, genetic counseling or the identification of human remains. In such instances a combined half-sibship index (CHSI) can be calculated. Support for this kinship is also based upon the number of shared-alleles at DNA loci. We report on the combination of the calculation of CHSI with the all-shared-alleles (ASA) to enhance the specificity of any half-sibship test. The 15 STR loci (including CODIS 13) that comprise the Identifiler loci were applied to three populations using 355,620 simulated pairs of half-siblings and 178,815 unrelated pairs. Based upon the data obtained, the sensitivity and specificity can be evaluated to determine the existence of half-sibship. This report highlights the uncertainty problems inherent in this form of indirect kinship testing and recommends a combination evaluation of CHSI and ASA.
半同胞关系是指两个兄弟姐妹仅共享一位父母。在移民、遗产继承、遗传咨询或人类遗骸鉴定等情况下，可能需要确定两个人是否为半同胞。在这种情况下，可以计算综合半同胞指数（CHSI）。对这种亲属关系的支持也基于DNA位点上共享等位基因的数量。我们报告了CHSI计算与全共享等位基因（ASA）的结合，以提高任何半同胞关系测试的特异性。使用355,620对模拟半同胞和178,815对无关个体对，将构成Identifiler位点的15个STR位点（包括CODIS 13）应用于三个人群。根据获得的数据，可以评估敏感性和特异性，以确定半同胞关系的存在。本报告强调了这种间接亲属关系测试形式中固有的不确定性问题，并建议对CHSI和ASA进行综合评估。
