Wander R C, Patton B D
Department of Nutrition and Food Management, Oregon State University, Corvallis 97331-5103.
Am J Clin Nutr. 1991 Aug;54(2):326-33. doi: 10.1093/ajcn/54.2.326.
This study examined the effect of the consumption of moderate amounts of three species of fish on platelet fatty acid profile (PFA), bleeding time (BT), platelet aggregation, and ex vivo production of thromboxane B2 (TXB2). Twenty-three healthy, young men consumed 200 g/d of Dover sole. Chinook salmon, and sablefish for 18 d in a three-way crossover design as part of a Western diet. Salmon and sablefish compared with sole caused significant increases in the eicosapentaenoic acid content of the PFA (P = 0.002). BT increased moderately when salmon diets were consumed (P = 0.06). Platelet aggregation decreased with collagen as an agonist on sablefish diets (P = 0.03) and with ADP as an agonist on salmon and sablefish diets (P = 0.04). TXB2 concentrations decreased moderately on sablefish and salmon diets (P = 0.06). Certain species of fish when consumed in reasonable amounts as part of a Western diet may cause modestly positive effects on platelet function.
本研究考察了适量食用三种鱼类对血小板脂肪酸谱（PFA）、出血时间（BT）、血小板聚集以及血栓素B2（TXB2）体外生成的影响。23名健康的年轻男性按照三交叉设计，作为西方饮食的一部分，连续18天每天食用200克多佛比目鱼、奇努克三文鱼和黑鳕鱼。与比目鱼相比，三文鱼和黑鳕鱼使PFA中的二十碳五烯酸含量显著增加（P = 0.002）。食用三文鱼饮食时，BT适度增加（P = 0.06）。以胶原蛋白为激动剂时，黑鳕鱼饮食使血小板聚集减少（P = 0.03）；以二磷酸腺苷（ADP）为激动剂时，三文鱼和黑鳕鱼饮食使血小板聚集减少（P = 0.04）。黑鳕鱼和三文鱼饮食使TXB2浓度适度降低（P = 0.06）。作为西方饮食的一部分，适量食用某些种类的鱼可能会对血小板功能产生适度的积极影响。
