Raes Jeroen, Bork Peer
European Molecular Biology Laboratory, Heidelberg, Germany.
Nat Rev Microbiol. 2008 Sep;6(9):693-9. doi: 10.1038/nrmicro1935.
Systems-biology approaches, which are driven by genome sequencing and high-throughput functional genomics data, are revolutionizing single-cell-organism biology. With the advent of various high-throughput techniques that aim to characterize complete microbial ecosystems (metagenomics, meta-transcriptomics and meta-metabolomics), we propose that the time is ripe to consider molecular systems biology at the ecosystem level (eco-systems biology). Here, we discuss the necessary data types that are required to unite molecular microbiology and ecology to develop an understanding of community function and discuss the potential shortcomings of these approaches.
由基因组测序和高通量功能基因组学数据驱动的系统生物学方法，正在彻底改变单细胞生物生物学。随着旨在表征完整微生物生态系统的各种高通量技术（宏基因组学、宏转录组学和宏代谢组学）的出现，我们认为现在时机已经成熟，可以在生态系统水平上考虑分子系统生物学（生态系统生物学）。在这里，我们讨论了将分子微生物学和生态学结合起来以理解群落功能所需的必要数据类型，并讨论了这些方法的潜在缺点。
