Skaar Jeffrey R, Pagano Michele
Department of Pathology, NYU Cancer Institute, New York University School of Medicine, 550 First Avenue, MSB 599, New York, NY 10016, USA.
Nat Cell Biol. 2008 Jul;10(7):755-7. doi: 10.1038/ncb0708-755.
APC/C(Cdh1) controls the G0 and G1 phases of the cell cycle. Using a conditional knockout of the Cdh1 coding gene Fizzy-related (Fzr), a new study demonstrates that Cdh1 is essential for viability and that it functions as a tumour suppressor by preventing genomic instability.
后期促进复合物/细胞周期体(Cdh1)调控细胞周期的G0期和G1期。一项新研究通过对Cdh1编码基因Fizzy相关蛋白(Fzr)进行条件性敲除,证明Cdh1对细胞存活至关重要,并且它通过防止基因组不稳定发挥肿瘤抑制作用。