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[睡眠呼吸障碍]

[Sleep disordered breathing].

作者信息

Dogas Zoran, Valić Maja, Pecotić Renata, Pupić Marija Cavar, Carev Mladen, Bojić Lovre, Racić Goran

机构信息

Katedra za neuroznanost i znanstvenu metodologiju, Medicinski fakultet u Splitu.

出版信息

Lijec Vjesn. 2008 Mar-Apr;130(3-4):69-77.

Abstract

Sleep apnea is a breathing disorder characterized by cessation of breathing during sleep, oxygen desaturation and awakenings during night. There are several types of breathing disorders during sleep. Obstructive sleep apnea (OSA) is also characterized by snoring and excessive daytime sleepiness. Central sleep apnea (CSA) is less common and characterized by reduced respiratory drive from the central nervous system. Upper airway resistance syndrome (UARS) is characterized by excessive daytime sleepiness, absence ofapneas, hypopneas and lack of significant oxygen desaturation. The consequences of the abnormal breathing during sleep include excessive daytime sleepiness, development of arterial hypertension, ischemic cardiac disease, neurocognitive dysfunction, glaucomic optico-neuropathy, metabolic dysfunction. The early diagnosis requires detailed anamnestic data, standardized questionnaires for detection of sleep disordered breathing and whole-night polysomnography in the sleep laboratory. Obstructive sleep apnea can be treated with continuous positive airway pressure (CPAP), oral appliances, and surgery (e.g., uvulopalatopharyngoplasty, UPPP). Early diagnosis of OSA enables early treatment, improvement of its symptoms and eventually reduces development of co-morbidities.

摘要

睡眠呼吸暂停是一种呼吸障碍,其特征为睡眠期间呼吸停止、夜间氧饱和度下降以及觉醒。睡眠期间存在多种呼吸障碍类型。阻塞性睡眠呼吸暂停(OSA)还伴有打鼾和日间过度嗜睡的特征。中枢性睡眠呼吸暂停(CSA)不太常见,其特征为中枢神经系统呼吸驱动力降低。上气道阻力综合征(UARS)的特征为日间过度嗜睡、无呼吸暂停、低通气且无明显氧饱和度下降。睡眠期间异常呼吸的后果包括日间过度嗜睡、动脉高血压、缺血性心脏病、神经认知功能障碍、青光眼性视神经病变、代谢功能障碍。早期诊断需要详细的病史资料、用于检测睡眠呼吸障碍的标准化问卷以及在睡眠实验室进行的整夜多导睡眠监测。阻塞性睡眠呼吸暂停可通过持续气道正压通气(CPAP)、口腔矫治器和手术(如悬雍垂腭咽成形术,UPPP)进行治疗。OSA的早期诊断能够实现早期治疗,改善其症状,并最终减少合并症的发生。

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