Inhibitory effect of bombesin and SMS 201-995 on DNA synthesis in the rat thyroid lobes incubated in vitro. - Suppr | 超能文献

Inhibitory effect of bombesin and SMS 201-995 on DNA synthesis in the rat thyroid lobes incubated in vitro.

作者信息

Lewiński A, Sewerynek E, Wajs E, Baranowska B, Zerek-Mełeń G, Kunert-Radek J

机构信息

Institute of Endocrinology, University School of Medicine, Poland.

出版信息

Biochem Biophys Res Commun. 1991 Jul 31;178(2):520-5. doi: 10.1016/0006-291x(91)90138-w.

DOI:10.1016/0006-291x(91)90138-w

Abstract

The effects of 4-h incubation in the presence of bombesin on the incorporation of [3H]-thymidine into DNA of the rat thyroid lobes, collected from animals treated in vivo with a long-acting somatostatin analog (SMS 201-995) or with 0.9% NaCl, were investigated. It was shown that not only in vivo injections of SMS 201-995, but also, unexpectedly, in vitro incubation with bombesin inhibited [3H]-thymidine incorporation. The two examined substances did not reveal any additive action in their inhibitory effects on the thyroid growth.

摘要

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