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1
Evaluation of lithium as an inhibitory agent of herpes simplex virus in cell cultures and during reactivation of latent infection in rabbits.锂作为单纯疱疹病毒在细胞培养物中以及兔潜伏感染再激活过程中的抑制剂的评估。
Antimicrob Agents Chemother. 1984 Apr;25(4):522-3. doi: 10.1128/AAC.25.4.522.
2
Effect of ibuprofen on the in vitro and in vivo reactivation of latent HSV-1.布洛芬对潜伏性单纯疱疹病毒1型体外和体内再激活的影响。
Oral Surg Oral Med Oral Pathol. 1992 Mar;73(3):321-7. doi: 10.1016/0030-4220(92)90129-e.
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Herpes simplex virus infection in guinea pigs: an animal model for studying latent and recurrent herpes simplex virus infection.豚鼠单纯疱疹病毒感染：一种用于研究单纯疱疹病毒潜伏和复发感染的动物模型。
Infect Immun. 1975 Jul;12(1):162-5. doi: 10.1128/iai.12.1.162-165.1975.
4
Effects of 2,2'-O-cyclocytidine and acyclovir on latent herpes simplex virus in trigeminal ganglia of mice.2,2'-O-环胞苷和阿昔洛韦对小鼠三叉神经节中潜伏单纯疱疹病毒的影响。
Antimicrob Agents Chemother. 1986 Feb;29(2):278-80. doi: 10.1128/AAC.29.2.278.
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Establishment of a nonproductive herpes simplex virus infection in rabbit kidney cells.在兔肾细胞中建立非增殖性单纯疱疹病毒感染。
Infect Immun. 1975 Jul;12(1):128-33. doi: 10.1128/iai.12.1.128-133.1975.
6
A possible antiviral action of lithium carbonate in herpes simplex virus infections.碳酸锂在单纯疱疹病毒感染中的一种可能的抗病毒作用。
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Novobiocin and coumermycin A1 inhibit viral replication and the reactivation of herpes simplex virus type 1 from the trigeminal ganglia of latently infected mice.新生霉素和香豆霉素A1可抑制病毒复制以及潜伏感染小鼠三叉神经节中单纯疱疹病毒1型的再激活。
J Virol. 1987 Oct;61(10):3288-91. doi: 10.1128/JVI.61.10.3288-3291.1987.
8
Effect of acyclovir on latent herpes simplex virus infections in trigeminal ganglia of mice.阿昔洛韦对小鼠三叉神经节中潜伏性单纯疱疹病毒感染的影响。
Antimicrob Agents Chemother. 1981 May;19(5):937-9. doi: 10.1128/AAC.19.5.937.
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5-Propyl-2'-deoxyuridine: a specific anti-herpes agent.5-丙基-2'-脱氧尿苷：一种特异性抗疱疹剂。
Antimicrob Agents Chemother. 1978 Mar;13(3):545-7. doi: 10.1128/AAC.13.3.545.
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Therapeutic immunization with a mixture of herpes simplex virus 1 glycoprotein D-derived “asymptomatic” human CD8+ T-cell epitopes decreases spontaneous ocular shedding in latently infected HLA transgenic rabbits: association with low frequency of local PD-1+ TIM-3+ CD8+ exhausted T cells.用单纯疱疹病毒1型糖蛋白D衍生的“无症状”人CD8 + T细胞表位混合物进行治疗性免疫可减少潜伏感染的HLA转基因兔的自发性眼部排毒：与局部PD-1 + TIM-3 + CD8 +耗竭性T细胞的低频率相关。
J Virol. 2015 Jul;89(13):6619-32. doi: 10.1128/JVI.00788-15.

引用本文的文献

1
Lithium's antiviral effects: a potential drug for CoViD-19 disease?锂的抗病毒作用：一种治疗新冠肺炎的潜在药物？
Int J Bipolar Disord. 2020 May 20;8(1):21. doi: 10.1186/s40345-020-00191-4.

本文引用的文献

1
Immunopotentiation and inhibition of herpes virus activation during therapy with lithium carbonate.碳酸锂治疗期间的免疫增强及对疱疹病毒激活的抑制作用
Med Hypotheses. 1981 Jul;7(7):885-90. doi: 10.1016/0306-9877(81)90043-8.
2
HSV-1 shedding by lontophoresis of 6-hydroxydopamine followed by topical epinephrine.通过6-羟基多巴胺电离子导入法继以局部应用肾上腺素来实现单纯疱疹病毒1型脱落。
Invest Ophthalmol Vis Sci. 1983 Dec;24(12):1588-94.
3
Activity of 1-(2'-fluoro-2'-deoxy-beta-D-arabinofuranosyl)thymine against herpes simplex virus in cell cultures and rabbit eyes.1-（2'-氟-2'-脱氧-β-D-阿拉伯呋喃糖基）胸腺嘧啶在细胞培养物和兔眼中对单纯疱疹病毒的活性
Antimicrob Agents Chemother. 1983 Jun;23(6):808-13. doi: 10.1128/AAC.23.6.808.
4
Evaluation of the antiherpetic activity of 2'-fluoro-5-iodo-ara-C in rabbit eyes and cell cultures.
Invest Ophthalmol Vis Sci. 1981 Dec;21(6):826-32.
5
The effect of lithium chloride on the replication of herpes simplex virus.氯化锂对单纯疱疹病毒复制的影响。
Med Microbiol Immunol. 1980;168(2):139-48. doi: 10.1007/BF02121762.
6
Biology of the lithium ion.锂离子生物学
Adv Exp Med Biol. 1980;127:15-59. doi: 10.1007/978-1-4757-0259-0_2.
7
Intracellular lithium concentration and clinical response: towards a membrane theory of depression.细胞内锂浓度与临床反应：迈向抑郁症的膜理论
J Psychiatr Res. 1973 Jun;10(1):9-18. doi: 10.1016/0022-3956(73)90005-8.
8
Accumulation of lithium in the particulate fraction of rat brain following its long-term administration.
J Neurochem. 1974 Dec;23(6):1299-301. doi: 10.1111/j.1471-4159.1974.tb12231.x.
9
Determination of plasma and erythrocyte lithium concentrations by atomic absorption spectrophotometry.用原子吸收分光光度法测定血浆和红细胞中的锂浓度。
Clin Chem. 1977 Jan;23(1):41-5.
10
Remission of recurrent herpes infection during therapy with lithium.锂盐治疗期间复发性疱疹感染的缓解
N Engl J Med. 1979 Oct 25;301(17):942. doi: 10.1056/nejm197910253011711.

锂作为单纯疱疹病毒在细胞培养物中以及兔潜伏感染再激活过程中的抑制剂的评估。

Evaluation of lithium as an inhibitory agent of herpes simplex virus in cell cultures and during reactivation of latent infection in rabbits.

作者信息

Trousdale M D, Gordon Y J, Peters A C, Gropen T I, Nelson E, Nesburn A B

出版信息

Antimicrob Agents Chemother. 1984 Apr;25(4):522-3. doi: 10.1128/AAC.25.4.522.

DOI:10.1128/AAC.25.4.522
PMID:6329084
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC185570/
Abstract

Lithium carbonate inhibited plaque formation of herpes simplex virus types 1 and 2 in rabbit kidney and Vero cells (50% effective dose, 435.5 to 490 micrograms/ml). Plasma lithium levels of 67 to 134 micrograms/ml were achieved by oral therapy in rabbits. However, neither ocular virus shedding nor virus-positive trigeminal ganglia were reduced after intentional reactivation of latent herpes simplex virus infection.

摘要

碳酸锂在兔肾细胞和非洲绿猴肾细胞中抑制1型和2型单纯疱疹病毒的斑块形成（半数有效剂量为435.5至490微克/毫升）。通过口服治疗使兔的血浆锂水平达到67至134微克/毫升。然而，在潜伏性单纯疱疹病毒感染被有意激活后，眼部病毒脱落和病毒阳性的三叉神经节均未减少。