锂作为单纯疱疹病毒在细胞培养物中以及兔潜伏感染再激活过程中的抑制剂的评估。
Evaluation of lithium as an inhibitory agent of herpes simplex virus in cell cultures and during reactivation of latent infection in rabbits.
作者信息
Trousdale M D, Gordon Y J, Peters A C, Gropen T I, Nelson E, Nesburn A B
出版信息
Antimicrob Agents Chemother. 1984 Apr;25(4):522-3. doi: 10.1128/AAC.25.4.522.
Abstract
Lithium carbonate inhibited plaque formation of herpes simplex virus types 1 and 2 in rabbit kidney and Vero cells (50% effective dose, 435.5 to 490 micrograms/ml). Plasma lithium levels of 67 to 134 micrograms/ml were achieved by oral therapy in rabbits. However, neither ocular virus shedding nor virus-positive trigeminal ganglia were reduced after intentional reactivation of latent herpes simplex virus infection.
摘要
碳酸锂在兔肾细胞和非洲绿猴肾细胞中抑制1型和2型单纯疱疹病毒的斑块形成（半数有效剂量为435.5至490微克/毫升）。通过口服治疗使兔的血浆锂水平达到67至134微克/毫升。然而，在潜伏性单纯疱疹病毒感染被有意激活后，眼部病毒脱落和病毒阳性的三叉神经节均未减少。
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