间日疟孕妇与非孕妇中氯喹的药代动力学
Chloroquine pharmacokinetics in pregnant and nonpregnant women with vivax malaria.
作者信息
Lee Sue Jean, McGready Rose, Fernandez Christine, Stepniewska Kasia, Paw Moo Koo, Viladpai-nguen Samuel Jacher, Thwai Kyaw Lay, Villegas Leopoldo, Singhasivanon Pratap, Greenwood Brian M, White Nicholas J, Nosten François
机构信息
Mahidol-Oxford Tropical Medicine Research Unit, MORU, Mahidol University, Bangkok, Thailand.
出版信息
Eur J Clin Pharmacol. 2008 Oct;64(10):987-92. doi: 10.1007/s00228-008-0500-z. Epub 2008 Jul 2.
PURPOSE
We compared the pharmacokinetics of chloroquine in pregnant and nonpregnant women treated for Plasmodium vivax malaria.
METHODS
Twelve pregnant women and 15 nonpregnant women of child-bearing age with acute P. vivax malaria were treated with 25 mg chloroquine base/kg over 3 days on the northwestern border of Thailand. Blood concentrations of chloroquine and desethylchloroquine were measured using hydrophilic interaction liquid chromatography coupled with fluorescence detection. Twenty-five women completed the pharmacokinetic study.
RESULTS
Although increasing gestational age was associated with reduced chloroquine AUC0-->infinity, there was no significant difference overall in the pharmacokinetics of chloroquine between pregnant and nonpregnant women. Fever was associated with lower chloroquine AUC0-->infinity values. Desethylchloroquine area under the curve (AUC) values were not significantly affected by pregnancy.
CONCLUSIONS
Pregnancy did not significantly affect blood concentrations of chloroquine or its metabolite, desethylchloroquine, in women with P. vivax malaria.
目的
我们比较了治疗间日疟原虫疟疾的孕妇和非孕妇中氯喹的药代动力学。
方法
在泰国西北边境，对12名孕妇和15名患有急性间日疟原虫疟疾的育龄非孕妇给予25mg氯喹碱基/千克，持续3天。使用亲水相互作用液相色谱结合荧光检测法测量氯喹和去乙基氯喹的血药浓度。25名女性完成了药代动力学研究。
结果
尽管孕周增加与氯喹AUC0→∞降低相关，但孕妇和非孕妇中氯喹的药代动力学总体上没有显著差异。发热与较低的氯喹AUC0→∞值相关。去乙基氯喹曲线下面积（AUC）值不受妊娠的显著影响。
结论
妊娠对患有间日疟原虫疟疾的女性中氯喹及其代谢产物去乙基氯喹的血药浓度没有显著影响。
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