疟疾孕妇氯喹治疗监测

Therapeutic monitoring of chloroquine in pregnant women with malaria.

作者信息

Fakeye T O, Fehintola F A, Ademowo O G, Walker O

机构信息

Department of Pharmaceutical Microbiology & Clinical Pharmacy, College of Medicine, University of Ibadan, Nigeria.

出版信息

West Afr J Med. 2002 Oct-Dec;21(4):286-7. doi: 10.4314/wajm.v21i4.27999.

DOI:10.4314/wajm.v21i4.27999

PMID:12665265

Abstract

Therapeutic monitoring of chloroquine was carried out in pregnant women with confirmed laboratory and clinical malaria after administration of 10 mg/kg body weight of the drug at 0 and 24th hour and 5 mg/kg body weight at the 48th hour. Venous blood was withdrawn at scheduled intervals. Plasma chloroquine level was determined using a highly sensitive and specific liquid chromatographic method. The time of peak plasma concentration, (t(max)) after the first dose was found to be 3.5 hours while peak plasma concentrations, (Cp(max)) were obtained at 2, 28, and 52 hours with values of 204. 36, 343.51 and 257.04 ng/ml respectively. There was total parasitaemia clearance before the end of 96 hours in all the subjects.

摘要

对确诊为实验室确诊和临床疟疾的孕妇进行氯喹治疗监测，在第0小时和第24小时给予10mg/kg体重的药物，第48小时给予5mg/kg体重的药物。按预定时间间隔采集静脉血。采用高灵敏度和特异性的液相色谱法测定血浆氯喹水平。首次给药后血浆浓度达峰时间（t(max)）为3.5小时，而在第2、28和52小时获得血浆峰浓度（Cp(max)），分别为204.36、343.51和257.04ng/ml。所有受试者在96小时结束前均实现了疟原虫血症完全清除。