Heat shock protein 90 modulates LRRK2 stability: potential implications for Parkinson's disease treatment.
作者信息
Hurtado-Lorenzo Andrés, Anand Vasanti S
机构信息
Neuroscience Discovery Research, Wyeth Research, Princeton, New Jersey 08543, USA.
出版信息
J Neurosci. 2008 Jul 2;28(27):6757-9. doi: 10.1523/JNEUROSCI.1870-08.2008.
Abstract
摘要
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Heat shock protein 90 modulates LRRK2 stability: potential implications for Parkinson's disease treatment.热休克蛋白90调节富含亮氨酸重复激酶2的稳定性：对帕金森病治疗的潜在影响。
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本文引用的文献
1
The chaperone activity of heat shock protein 90 is critical for maintaining the stability of leucine-rich repeat kinase 2.热休克蛋白90的伴侣活性对于维持富含亮氨酸重复激酶2的稳定性至关重要。
J Neurosci. 2008 Mar 26;28(13):3384-91. doi: 10.1523/JNEUROSCI.0185-08.2008.
2
A Drosophila model for LRRK2-linked parkinsonism.一种与LRRK2相关帕金森病的果蝇模型。
Proc Natl Acad Sci U S A. 2008 Feb 19;105(7):2693-8. doi: 10.1073/pnas.0708452105. Epub 2008 Feb 7.
3
Drug-mediated targeted disruption of multiple protein activities through functional inhibition of the Hsp90 chaperone complex.通过对热休克蛋白90（Hsp90）伴侣复合物的功能抑制，药物介导的多种蛋白质活性的靶向破坏。
Curr Med Chem. 2007;14(29):3122-38. doi: 10.2174/092986707782793925.
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Development and application of Hsp90 inhibitors.热休克蛋白90（Hsp90）抑制剂的研发与应用
Drug Discov Today. 2008 Jan;13(1-2):38-43. doi: 10.1016/j.drudis.2007.10.007. Epub 2007 Nov 26.
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Parkinson disease, 10 years after its genetic revolution: multiple clues to a complex disorder.帕金森病，基因革命十年后：复杂疾病的多重线索
Neurology. 2007 Nov 27;69(22):2093-104. doi: 10.1212/01.wnl.0000271880.27321.a7. Epub 2007 Aug 29.
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7
The high-affinity HSP90-CHIP complex recognizes and selectively degrades phosphorylated tau client proteins.高亲和力的HSP90-CHIP复合物识别并选择性降解磷酸化的tau客户蛋白。
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8
Novel pharmacological targets for the treatment of Parkinson's disease.治疗帕金森病的新型药理学靶点。
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LRRK2: a common pathway for parkinsonism, pathogenesis and prevention?富亮氨酸重复激酶2：帕金森病、发病机制与预防的共同途径？
Trends Mol Med. 2006 Feb;12(2):76-82. doi: 10.1016/j.molmed.2005.12.004. Epub 2006 Jan 10.
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