Dighiero G, Hart S, Lim A, Borche L, Levy R, Miller R A
Institut Pasteur, Paris, France.
Blood. 1991 Aug 1;78(3):581-5.
Previous work with monoclonal Igs (MIgs) has demonstrated that a high proportion of paraproteins bind to self-antigens such as the Fc fragment of IgG, Ii blood group antigens, cytoskeleton proteins, DNA, and myelin-associated glycoprotein (MAG). Recent work in CLL indicates that CD5+ B lymphocytes are frequently committed to production of autoantibodies. We have examined the antibody specificity of MIgs derived from the tumor cells of 31 different patients with CD5- B-cell lymphomas. Our results indicate that the tumor cells from 8 of these 31 patients (25.8%) express Igs with autoantibody activity. In two cases antibody activity was multispecific. In four cases, antibody activity was exclusively directed against the Fc fragment of IgG, whereas the two other cases bound to both Fc fragment of IgG and nuclear antigens. Most non-Hodgkin's lymphomas (NHL) are derived from CD5- B cells. These results indicate that like CLL, NHL also express Igs that frequently have autoantibody activity.
先前针对单克隆免疫球蛋白（MIgs）的研究表明，很大一部分副蛋白能与自身抗原结合，如IgG的Fc片段、Ii血型抗原、细胞骨架蛋白、DNA以及髓鞘相关糖蛋白（MAG）。近期对慢性淋巴细胞白血病（CLL）的研究表明，CD5⁺ B淋巴细胞常倾向于产生自身抗体。我们检测了来自31例不同CD5⁻ B细胞淋巴瘤患者肿瘤细胞的MIgs的抗体特异性。我们的结果表明，这31例患者中有8例（25.8%）的肿瘤细胞表达具有自身抗体活性的免疫球蛋白。在两例中，抗体活性是多特异性的。在四例中，抗体活性仅针对IgG的Fc片段，而另外两例则与IgG的Fc片段和核抗原均有结合。大多数非霍奇金淋巴瘤（NHL）源自CD5⁻ B细胞。这些结果表明，与CLL一样，NHL也表达常具有自身抗体活性的免疫球蛋白。
