Kjelstrup Kirsten Brun, Solstad Trygve, Brun Vegard Heimly, Hafting Torkel, Leutgeb Stefan, Witter Menno P, Moser Edvard I, Moser May-Britt
Kavli Institute for Systems Neuroscience and Centre for the Biology of Memory, Norwegian University of Science and Technology, 7489 Trondheim, Norway.
Science. 2008 Jul 4;321(5885):140-3. doi: 10.1126/science.1157086.
To determine how spatial scale is represented in the pyramidal cell population of the hippocampus, we recorded neural activity at multiple longitudinal levels of this brain area while rats ran back and forth on an 18-meter-long linear track. CA3 cells had well-defined place fields at all levels. The scale of representation increased almost linearly from <1 meter at the dorsal pole to approximately 10 meters at the ventral pole. The results suggest that the place-cell map includes the entire hippocampus and that environments are represented in the hippocampus at a topographically graded but finite continuum of scales.
为了确定海马体锥体细胞群体中空间尺度是如何被表征的，我们在大鼠在一条18米长的直线轨道上来回奔跑时，记录了该脑区多个纵向水平的神经活动。CA3细胞在所有水平上都有明确的位置野。表征尺度从背侧极的小于1米几乎呈线性增加到腹侧极的约10米。结果表明，位置细胞图谱涵盖了整个海马体，并且环境在海马体中以地形学分级但有限的连续尺度来表征。
