海藻糖及其转运蛋白在抵御活性氧中的作用。
The role of trehalose and its transporter in protection against reactive oxygen species.
作者信息
da Costa Morato Nery Débora, da Silva Carmelita Gomes, Mariani Diana, Fernandes Patrícia Neves, Pereira Marcos Dias, Panek Anita Dolly, Eleutherio Elis Cristina Araújo
机构信息
Departamento de Bioquímica, Instituto de Química, UFRJ, 21941-909 Rio de Janeiro, RJ, Brazil.
出版信息
Biochim Biophys Acta. 2008 Dec;1780(12):1408-11. doi: 10.1016/j.bbagen.2008.05.011. Epub 2008 Jun 5.
During menadione stress, trehalose was necessary intracellularly, but under H2O2, the sugar was required on the outside of the plasma membrane. The mechanism of protection involves minimizing the oxidative damage caused to both proteins and lipids, which would require the presence of trehalose on both sides of the lipid bilayer.
在甲萘醌胁迫下，海藻糖在细胞内是必需的，但在过氧化氢作用下，这种糖类在质膜外侧是必需的。保护机制包括将对蛋白质和脂质造成的氧化损伤降至最低，这需要在脂质双层的两侧都存在海藻糖。
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