Bastidas Ramírez B E, Navarro Ruíz N, Quezada Arellano J D, Ruíz Madrigal B, Villanueva Michel M T, Garzón P
Departamento de Fisiología, Centro Universitario en Ciencias de la Salud, Universidad de Guadalajara, Jalisco, Mexico.
J Ethnopharmacol. 1998 Jun;61(2):143-52. doi: 10.1016/s0378-8741(98)00028-2.
The ethyl ether (EE) and hydroalcoholic extract (HE) of Magnolia grandiflora L. (Magnoliaceae) seeds, a popular plant utilized in the Mexican traditional medicine because of its antispasmodic as well as other reported pharmacological effects, were studied in adult male Wistar rats. EE and HE orally administered in a single dose of 250 mg/kg (calculated on lipidic base) and 200 mg/kg, exhibited abolition of the extensor reflex of maximal electric induced-seizure test in 50 and 40% of the experimental animals, respectively. They significantly prolonged the sleeping time induced by pentobarbital and only the ethanol extract induced hypothermia. No neurological deficit was exhibited by either extract according to the gait, stance and righting test. Although ulterior toxicological and pharmacological insight is necessary, these results suggest that the chemical constituents of this plant could have utility in the control of epileptic patients presenting convulsive seizures.
广玉兰（木兰科）种子的乙醚提取物（EE）和水醇提取物（HE），这种因具有解痉及其他报道的药理作用而在墨西哥传统医学中常用的植物，在成年雄性Wistar大鼠身上进行了研究。EE和HE分别以250 mg/kg（基于脂质计算）和200 mg/kg的单剂量口服给药，在50%和40%的实验动物中分别表现出消除最大电诱导惊厥试验的伸肌反射。它们显著延长了戊巴比妥诱导的睡眠时间，并且只有乙醇提取物诱导体温过低。根据步态、姿势和翻正试验，两种提取物均未表现出神经功能缺损。尽管需要进一步的毒理学和药理学研究，但这些结果表明该植物的化学成分可能对控制出现惊厥发作的癫痫患者有用。
