BK21 Project Team, College of Pharmacy and Department of Pathology, College of Medicine, Chosun University, Seosuk-dong, Dong-gu, Gwangju 501-759, Department of Prescription, College of Oriental Medicine, Daegu Haany University, Daegu 706-060 and College of Biomedical Laboratory Science, Konyang University, Daejeon, South Korea.
Evid Based Complement Alternat Med. 2008 Jun;5(2):173-80. doi: 10.1093/ecam/nem015.
Sopungyangjae-Tang (SYT) is a traditional Korean decoction used for the treatment of dermatitis. The aim of this study was to confirm whether or not SYT has a preventive effect on the development of atopic dermatitis in dinitrochlorobenzene-applied Nc/Nga mice. SYT was administered orally to Nc/Nga mice, which led to the remarkable suppression of the development of dermatitis, as determined by a histological examination and the serum IgE levels. Moreover, SYT inhibited the production of thymus- and activation-regulated chemokine (TARC) and its mRNA expression in a keratinocyte cell line, HaCaT, which had been stimulated with tumor necrosis factor-alpha (TNF-alpha) and interferon-gamma (IFN-gamma). Activation of the nuclear factor-kappaB (NF-kappaB) or activator protein-1 (AP-1) is one of the key steps in the signaling pathways mediating induction of TARC. In this study, SYT selectively suppressed NF-kappaB activation, which may be essential for TARC expression in TNF-alpha/IFN-gamma treated keratinocytes. The inhibitory effect of SYT on NF-kappaB activation and TARC production might be associated with the anti-dermatitic effects of SYT.
松蕈饮（SYT）是一种传统的韩国方剂，用于治疗皮炎。本研究旨在确认 SYT 是否对二硝基氯苯（DNCB）处理的 Nc/Nga 小鼠特应性皮炎的发展具有预防作用。通过组织学检查和血清 IgE 水平，SYT 可显著抑制皮炎的发展。此外，SYT 抑制了 TNF-α和 IFN-γ刺激的角质形成细胞系 HaCaT 中胸腺激活调节趋化因子（TARC）及其 mRNA 表达的产生。核因子-κB（NF-κB）或激活蛋白-1（AP-1）的激活是介导 TARC 诱导的信号通路中的关键步骤之一。在这项研究中，SYT 选择性地抑制了 NF-κB 的激活，这可能对 TNF-α/IFN-γ处理的角质形成细胞中 TARC 的表达至关重要。SYT 对 NF-κB 激活和 TARC 产生的抑制作用可能与 SYT 的抗皮炎作用有关。
