调查印度柿属植物的抗疟特性。
Investigation of Indian diospyros species for antiplasmodial properties.
机构信息
The School of Pharmacy, University of Bradford, West Yorkshire, BD7 1DP, UK.
出版信息
Evid Based Complement Alternat Med. 2008 Jun;5(2):187-90. doi: 10.1093/ecam/nem019.
Despite decades of intense research, malaria remains a deadly disease worldwide and new antimalarials are urgently needed due to increasing drug resistance of Plasmodium falciparum to existing drugs. This article reports the evaluation of four Indian Diospyros species viz., Diospyros melanoxylon, D. peregrina, D. sylvatica, D. tomentosa for antiplasmodial activities against chloroquine-sensitive (3D7) and chloroquine-resistant (K1) strains of P. falciparum. Six of eight methanolic extracts were found to have significant activity, (IC(50) = 16.5-92.9 microg ml(-1)), against strain 3D7 and five of these showed similar activities against strain K1 (IC(50) = 20.5-121.6 microg ml(-1)). Diospyros sylvatica was found to be the most active species (IC(50) = 16.5-29.4 microg ml(-1)) and is worthy of further investigation.
尽管经过几十年的深入研究，疟疾仍然是全球范围内的一种致命疾病，由于恶性疟原虫对现有药物的耐药性不断增加，迫切需要新的抗疟药物。本文报道了对四种印度柿属植物（Diospyros melanoxylon、D. peregrina、D. sylvatica 和 D. tomentosa）进行抗疟活性评价的研究，这些植物针对氯喹敏感（3D7）和氯喹耐药（K1）株的疟原虫。结果发现，有八种甲醇提取物中的六种对 3D7 株具有显著的活性（IC50=16.5-92.9μg/ml），其中五种对 K1 株也表现出相似的活性（IC50=20.5-121.6μg/ml）。D. sylvatica 被发现是最具活性的物种（IC50=16.5-29.4μg/ml），值得进一步研究。
Zotero 插件