Trongsakul S, Panthong A, Kanjanapothi D, Taesotikul T
Department of Pharmacology, Faculty of Medicine, Chiang Mai University, 50200, Chiang Mai, Thailand.
J Ethnopharmacol. 2003 Apr;85(2-3):221-5. doi: 10.1016/s0378-8741(03)00020-5.
Pharmacological studies were conducted with the hexane extract of the dry stem of Diospyros variegata Kruz. (Ebenaceae) on experimental animals for evaluating the analgesic, antipyretic and anti-inflammatory activities. In the analgesic test, the hexane extract elicited inhibitory intensity on acetic acid-induced writhing response and on the late phase of formalin test but possessed only a weak effect on the tail-flick response and on the early phase of formalin test. The hexane extract also elicited antipyretic action when tested in yeast-induced hyperthermia in rats. In addition, the hexane extract showed an anti-inflammatory effect when tested in ethyl phenylpropiolate (EPP)- and arachidonic acid (AA)-induced rat ear edema.
对柿科植物罗浮柿（Diospyros variegata Kruz.）干燥茎的己烷提取物进行了药理研究，以评估其在实验动物中的镇痛、解热和抗炎活性。在镇痛试验中，己烷提取物对醋酸诱导的扭体反应和福尔马林试验的后期具有抑制作用，但对甩尾反应和福尔马林试验的早期作用较弱。在大鼠酵母诱导的发热试验中，己烷提取物也表现出解热作用。此外，在苯丙炔酸乙酯（EPP）和花生四烯酸（AA）诱导的大鼠耳水肿试验中，己烷提取物显示出抗炎作用。
