混合的Th1和Th2血清细胞因子在汉坦病毒肺综合征发病机制及预后中的作用

Role of mixed Th1 and Th2 serum cytokines on pathogenesis and prognosis of hantavirus pulmonary syndrome.

作者信息

Borges Alessandra Abel, Campos Gelse Mazzoni, Moreli Marcos Lázaro, Moro Souza Ricardo Luiz, Saggioro Fabiano Pinto, Figueiredo Glauciane Garcia, Livonesi Márcia Cristina, Moraes Figueiredo Luiz Tadeu

机构信息

Virology Research Center, School of Medicine of Ribeirão Preto, University of São Paulo (USP), Av. Bandeirantes 3900, Ribeirão Preto, São Paulo State, 14049-900, Brazil.

出版信息

Microbes Infect. 2008 Aug-Sep;10(10-11):1150-7. doi: 10.1016/j.micinf.2008.06.006. Epub 2008 Jun 18.

DOI:10.1016/j.micinf.2008.06.006

PMID:18606242

Abstract

The hantavirus pulmonary syndrome (HPS) is an emerging syndrome in the Americas. The disease results from intense immune activation and changes in vascular permeability. The aim of this study was to determine the profile of serum cytokines in HPS patients looking for correlation with the clinical parameters, severity and outcome of illness. Studying 21 HPS patients, we found that IL-6 may have an important role in the pathogenesis of HPS, being associated with fatal outcome. Our results also support a mixed Th1/Th2 immune response during the course of HPS and that the magnitude of Th1 response effector cytokines is correlated to HPS severity. The decreased levels of TGF-beta observed in HPS patients suggest that immunoregulatory activity could be damaged in these patients.

摘要

汉坦病毒肺综合征（HPS）是美洲出现的一种综合征。该疾病是由强烈的免疫激活和血管通透性变化引起的。本研究的目的是确定HPS患者血清细胞因子谱，以寻找其与临床参数、疾病严重程度和转归的相关性。通过对21例HPS患者的研究，我们发现IL-6可能在HPS发病机制中起重要作用，与致命转归相关。我们的结果还支持HPS病程中存在Th1/Th2混合免疫反应，且Th1反应效应细胞因子的水平与HPS严重程度相关。HPS患者中观察到的TGF-β水平降低表明这些患者的免疫调节活性可能受损。