Gómez-Puerta José A, Burlingame Rufus W, Cervera Ricard
Department of Autoimmune Diseases, Hospital Clínic, Barcelona, Catalonia, Spain.
Autoimmun Rev. 2008 Sep;7(8):606-11. doi: 10.1016/j.autrev.2008.06.005. Epub 2008 Jul 9.
Anti-chromatin (nucleosome) autoantibodies were one of the first autoantibodies ever detected since they make up the majority of antibodies causing LE Cell formation. The prevalence of anti-chromatin antibodies in systemic lupus erythematosus (SLE) varies from 50% to 100%, being similar to that of the classical positive LE cell. The presence of these antibodies can be used, in conjunction with clinical findings and other laboratory tests, to help in the diagnosis of SLE and drug-induced lupus. Anti-chromatin antibodies have also been found in a lesser percentage of other autoimmune disorders such as primary Sjögren's syndrome and primary antiphospholipid syndrome. The presence of anti-chromatin antibodies has also been linked to glomerulonephritis and disease activity in SLE patients. Recent studies demonstrated the induction of anti-chromatin (anti-nucleosome) antibodies after an anti-tumour necrosis factor (TNF)-alpha agent treatment.
抗染色质（核小体）自身抗体是最早被检测到的自身抗体之一，因为它们构成了导致LE细胞形成的大多数抗体。系统性红斑狼疮（SLE）中抗染色质抗体的患病率在50%至100%之间，与经典阳性LE细胞的患病率相似。这些抗体的存在可与临床发现及其他实验室检查相结合，以帮助诊断SLE和药物性狼疮。在其他自身免疫性疾病如原发性干燥综合征和原发性抗磷脂综合征中也发现了较低比例的抗染色质抗体。抗染色质抗体的存在还与SLE患者的肾小球肾炎和疾病活动有关。最近的研究表明，在使用抗肿瘤坏死因子（TNF）-α药物治疗后会诱导产生抗染色质（抗核小体）抗体。
