Barry Stephen E
Alnis BioSciences, Inc., Research Triangle Park, NC 27709, USA.
Int J Hyperthermia. 2008 Sep;24(6):451-66. doi: 10.1080/02656730802093679.
Certain iron-based particle formulations have useful magnetic properties that, when combined with low toxicity and desirable pharmacokinetics, encourage their development for therapeutic applications. This mini-review begins with background information on magnetic particle use as MRI contrast agents and the influence of material size on pharmacokinetics and tissue penetration. Therapeutic investigations, including (1) the loading of bioactive materials, (2) the use of stationary, high-gradient (HG) magnetic fields to concentrate magnetic particles in tissues or to separate material bound to the particles from the body, and (3) the application of high power alternating magnetic fields (AMF) to generate heat in magnetic particles for hyperthermic therapeutic applications are then surveyed. Attention is directed mainly to cancer treatment, as selective distribution to tumors is well-suited to particulate approaches and has been a focus of most development efforts. While magnetic particles have been explored for several decades, their use in therapeutic products remains minimal; a discussion of future directions and potential ways to better leverage magnetic properties and to integrate their use into therapeutic regimens is discussed.
某些铁基颗粒制剂具有有用的磁性，当与低毒性和理想的药代动力学相结合时，会促使它们被开发用于治疗应用。本综述首先介绍了磁性颗粒作为磁共振成像（MRI）造影剂的背景信息，以及材料尺寸对药代动力学和组织穿透性的影响。然后对治疗研究进行了综述，包括（1）生物活性材料的负载，（2）使用静态高梯度（HG）磁场将磁性颗粒集中在组织中或从体内分离与颗粒结合的物质，以及（3）应用高功率交变磁场（AMF）在磁性颗粒中产生热量以用于热疗应用。主要关注癌症治疗，因为肿瘤的选择性分布非常适合颗粒方法，并且一直是大多数开发工作的重点。虽然磁性颗粒已经被研究了几十年，但它们在治疗产品中的应用仍然很少；本文讨论了未来的方向以及更好地利用磁性并将其应用整合到治疗方案中的潜在方法。
