Sabit Hussein, Abdel-Hakeem Mohamed, Shoala Tahsin, Abdel-Ghany Shaimaa, Abdel-Latif Mokhtar Mamdouh, Almulhim Jawaher, Mansy Mohamed
Department of Medical Biotechnology, College of Biotechnology, Misr University for Science and Technology, Giza P.O. Box 77, Egypt.
Department of Pharmaceutical Biotechnology, College of Biotechnology, Misr University for Science and Technology, Giza P.O. Box 77, Egypt.
Pharmaceutics. 2022 Jul 28;14(8):1566. doi: 10.3390/pharmaceutics14081566.
Nanomedicines have gained popularity due to their potential therapeutic applications, especially cancer treatment. Targeted nanoparticles can deliver drugs directly to cancer cells and enable prolonged drug release, reducing off-target toxicity and increasing therapeutic efficacy. However, translating nanomedicines from preclinical to clinical settings has been difficult. Rapid advancements in nanotechnology promise to enhance cancer therapies. Nanomedicine offers advanced targeting and multifunctionality. Nanoparticles (NPs) have several uses nowadays. They have been studied as drug transporters, tumor gene delivery agents, and imaging contrast agents. Nanomaterials based on organic, inorganic, lipid, or glycan substances and synthetic polymers have been used to enhance cancer therapies. This review focuses on polymeric nanoparticle delivery strategies for anticancer nanomedicines.
纳米药物因其潜在的治疗应用，尤其是癌症治疗，而受到广泛关注。靶向纳米颗粒可以将药物直接递送至癌细胞，并实现药物的长效释放，从而降低脱靶毒性并提高治疗效果。然而，将纳米药物从临床前研究转化到临床应用一直存在困难。纳米技术的快速发展有望改善癌症治疗。纳米药物具有先进的靶向性和多功能性。纳米颗粒（NPs）如今有多种用途。它们已被研究用作药物转运体、肿瘤基因递送剂和成像造影剂。基于有机、无机、脂质或聚糖物质以及合成聚合物的纳米材料已被用于增强癌症治疗。本综述聚焦于抗癌纳米药物的聚合物纳米颗粒递送策略。
