Hubei Engineering Research Center of Selenium Food Nutrition and Health Intelligent Technology College of Biological and Food Engineering, Hubei Minzu University, Enshi, 445000, China.
Department of Medical Genetics and Cell Biology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, 450001, China.
Curr Microbiol. 2024 Sep 2;81(10):336. doi: 10.1007/s00284-024-03866-8.
Fatty acids (FAs) participate in extensive physiological activities such as energy metabolism, transcriptional control, and cell signaling. In bacteria, FAs are degraded and utilized through various metabolic pathways, including β-oxidation. Over the past ten years, significant progress has been made in studying FA oxidation in bacteria, particularly in E. coli, where the processes and roles of FA β-oxidation have been comprehensively elucidated. Here, we provide an update on the new research achievements in FAs β-oxidation in bacteria. Using Xanthomonas as an example, we introduce the oxidation process and regulation mechanism of the DSF-family quorum sensing signal. Based on current findings, we propose the specific enzymes required for β-oxidation of several specific FAs. Finally, we discuss the future outlook on scientific issues that remain to be addressed. This paper supplies theoretical guidance for further study of the FA β-oxidation pathway with particular emphasis on its connection to the pathogenicity mechanisms of bacteria.
脂肪酸（FAs）参与广泛的生理活动，如能量代谢、转录调控和细胞信号转导。在细菌中，脂肪酸通过各种代谢途径进行降解和利用，包括β-氧化。在过去的十年中，细菌中 FA 氧化的研究取得了重大进展，特别是在大肠杆菌中，FAβ-氧化的过程和作用得到了全面阐明。在这里，我们提供了细菌中 FAβ-氧化的最新研究成果。我们以黄单胞菌为例，介绍了 DSF 家族群体感应信号的氧化过程和调控机制。基于目前的研究结果，我们提出了β-氧化几种特定 FA 所需的特定酶。最后，我们讨论了仍然存在的科学问题的未来展望。本文为进一步研究 FAβ-氧化途径提供了理论指导，特别强调了其与细菌致病性机制的联系。
