Centre d'Ingénierie des Protéines, Université de Liège, Liège, Belgium.
Int J Antimicrob Agents. 1997 Feb;8(1):45-60. doi: 10.1016/s0924-8579(96)00358-5.
The assembly of the bacterial cell wall peptidoglycan relies upon the availability of a ready-made precursor, the lipid II intermediate. This intermediate is taken up by a multifunctional factory that provides the required enzymatic activities for polymer assembly at the exterior of the plasma membrane. Morphogenetic networks regulate the synthesis in a cell-cycle-dependent fashion. As essential components of the cell machinery are targets of beta-lactam antibiotics, safety devices protect the cells against these toxic agents. Controversy and consensus formation lie at the heart of the scientific research. This review focuses on questions that bacterial cell wall biochemists still strive, with increasing success, to answer.
细菌细胞壁肽聚糖的组装依赖于现成的前体，即脂质 II 中间体。这种中间体被一个多功能工厂吸收，该工厂提供了在质膜外部进行聚合物组装所需的酶活性。形态发生网络以细胞周期依赖性的方式调节合成。由于细胞机制的基本组成部分是β-内酰胺类抗生素的靶标，因此安全装置可以保护细胞免受这些有毒物质的侵害。争议和共识的形成是科学研究的核心。这篇综述重点介绍了细菌细胞壁生物化学家仍在努力回答的问题，并且随着研究的不断深入，他们已经取得了越来越多的成功。
