花青素-3-半乳糖苷的α-葡萄糖苷酶抑制活性及其与阿卡波糖的协同作用。
alpha-Glucosidase inhibitory activity of cyanidin-3-galactoside and synergistic effect with acarbose.
作者信息
Adisakwattana Sirichai, Charoenlertkul Piyawan, Yibchok-Anun Sirintorn
机构信息
Department of Transfusion Medicine, Faculty of Allied Health Sciences, Chulalongkorn University, Bangkok, Thailand.
出版信息
J Enzyme Inhib Med Chem. 2009 Feb;24(1):65-9. doi: 10.1080/14756360801906947.
Cyanidin-3-galactoside, a natural anthocyanin, was investigated for its alpha-glucosidase inhibitory activity. The IC(50) value of cyanidin-3-galactoside was 0.50 +/- 0.05 mM against intestinal sucrase. A low dose of cyanidin-3-galactoside showed a synergistic inhibition on intestinal alpha-glucosidase (maltase and sucrase) when combined with acarbose. A kinetic analysis showed that cyanidin-3-galactoside gave a mixed type inhibition against intestinal sucrase. The results indicated that cyanidin-3-galactoside was an alpha-glucosidase inhibitor and could be used in combination with acarbose for treatment of diabetes.
矢车菊素 - 3 - 半乳糖苷，一种天然花青素，对其α - 葡萄糖苷酶抑制活性进行了研究。矢车菊素 - 3 - 半乳糖苷对肠道蔗糖酶的IC(50)值为0.50±0.05 mM。低剂量的矢车菊素 - 3 - 半乳糖苷与阿卡波糖联合使用时，对肠道α - 葡萄糖苷酶（麦芽糖酶和蔗糖酶）表现出协同抑制作用。动力学分析表明，矢车菊素 - 3 - 半乳糖苷对肠道蔗糖酶产生混合型抑制作用。结果表明，矢车菊素 - 3 - 半乳糖苷是一种α - 葡萄糖苷酶抑制剂，可与阿卡波糖联合用于糖尿病治疗。
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