Droege Marcus, Hill Brendon
Roche Applied Science, Global Marketing, 82372 Penzberg, Germany.
J Biotechnol. 2008 Aug 31;136(1-2):3-10. doi: 10.1016/j.jbiotec.2008.03.021. Epub 2008 Jun 21.
The Genome Sequencer FLX System (GS FLX), powered by 454 Sequencing, is a next-generation DNA sequencing technology featuring a unique mix of long reads, exceptional accuracy, and ultra-high throughput. It has been proven to be the most versatile of all currently available next-generation sequencing technologies, supporting many high-profile studies in over seven applications categories. GS FLX users have pursued innovative research in de novo sequencing, re-sequencing of whole genomes and target DNA regions, metagenomics, and RNA analysis. 454 Sequencing is a powerful tool for human genetics research, having recently re-sequenced the genome of an individual human, currently re-sequencing the complete human exome and targeted genomic regions using the NimbleGen sequence capture process, and detected low-frequency somatic mutations linked to cancer.
由454测序技术驱动的基因组测序仪FLX系统（GS FLX）是一种新一代DNA测序技术，具有长读长、超高准确性和超高通量的独特组合。它已被证明是目前所有可用的新一代测序技术中用途最广泛的，支持超过七个应用类别的许多备受瞩目的研究。GS FLX用户已在从头测序、全基因组和目标DNA区域的重测序、宏基因组学及RNA分析方面开展了创新性研究。454测序技术是人类遗传学研究的强大工具，最近已对一个人的基因组进行了重测序，目前正在使用NimbleGen序列捕获方法对完整的人类外显子组和目标基因组区域进行重测序，并检测到了与癌症相关的低频体细胞突变。
