地中海饮食对皮肤黑色素瘤的保护作用。

A protective effect of the Mediterranean diet for cutaneous melanoma.

作者信息

Fortes C, Mastroeni S, Melchi F, Pilla M A, Antonelli G, Camaioni D, Alotto M, Pasquini P

机构信息

Clinical Epidemiology Unit, Istituto Dermopatico dell'Immacolata, IDI-IRCCS, Via dei Monti di Creta, 104, 00167 Rome, Italy.

出版信息

Int J Epidemiol. 2008 Oct;37(5):1018-29. doi: 10.1093/ije/dyn132. Epub 2008 Jul 11.

DOI:10.1093/ije/dyn132

PMID:18621803

Abstract

BACKGROUND

Many studies have investigated the Mediterranean diet as a risk factor for cancer, none of which has included cutaneous melanoma. The latter is usually fatal, rendering knowledge about prevention extremely important. We assessed the role of some food components of the Mediterranean diet and cutaneous melanoma.

METHODS

A hospital-based case-control study was conducted in the inpatient wards of IDI-San Carlo Rome, Italy including 304 incident cases of cutaneous melanoma and 305 controls, frequency matched to cases. Information on socio-demographic characteristics, medical history, smoking, sun exposure, pigmentary characteristics and diet was collected. Logistic regression was the method used to estimated odds ratio and 95% CIs.

RESULTS

After careful control for several sun exposure and pigmentary characteristics, we found a protective effect for weekly consumption of fish (OR, 0.65, 95%CI = 0.43-0.97), shellfish (OR, 0.53, 95%CI = 0.31-0.89), fish rich in n-3 fatty acids (OR, 0.52, 95%CI = 0.34-0.78), daily tea drinking (OR, 0.42, 95%CI, 0.18-0.95; P(trend) = 0.025) and high consumption of vegetables (OR, 0.50, 95%CI = 0.31-0.80, P(trend) = 0.005) in particular carrots, cruciferous and leafy vegetables and fruits (OR, 0.54, 95%CI =0.33-0.86, P(trend) = 0.013), in particular citrus fruits. No association was found for alcohol consumption and any other food items.

CONCLUSION

Overall, our findings suggest that some dietary factors present in the Mediterranean diet might protect from cutaneous melanoma.

摘要

背景

许多研究调查了地中海饮食作为癌症的一个风险因素，但均未纳入皮肤黑色素瘤。后者通常是致命的，因此了解其预防方法极为重要。我们评估了地中海饮食中的一些食物成分与皮肤黑色素瘤的关系。

方法

在意大利罗马圣卡罗IDI医院的住院病房开展了一项基于医院的病例对照研究，纳入304例皮肤黑色素瘤新发病例和305例对照，对照与病例进行频率匹配。收集了社会人口学特征、病史、吸烟、日晒、色素沉着特征和饮食等信息。采用逻辑回归方法估计比值比和95%置信区间。

结果

在仔细控制了多种日晒和色素沉着特征后，我们发现每周食用鱼类（比值比，0.65，95%置信区间=0.43-0.97）、贝类（比值比，0.53，95%置信区间=0.31-0.89）、富含n-3脂肪酸的鱼类（比值比，0.52，95%置信区间=0.34-0.78）、每日饮茶（比值比，0.42，95%置信区间，0.18-0.95；趋势P值=0.025）以及大量食用蔬菜（比值比，0.50，95%置信区间=0.31-0.80，趋势P值=0.005），特别是胡萝卜、十字花科蔬菜和叶菜类蔬菜以及水果（比值比，0.54，95%置信区间=0.33-0.86，趋势P值=0.013），特别是柑橘类水果，具有保护作用。未发现饮酒与任何其他食物项目之间存在关联。