Ophthalmic Epidemiology Research Center, Research Institute for Ophthalmology and Vision Science, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Department of Optometry, School of Rehabilitation, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
BMC Cancer. 2023 Sep 30;23(1):924. doi: 10.1186/s12885-023-11414-z.
Eyelid skin cancers are the most prevalent ophthalmic malignancies. This study aimed to evaluate the association of the Human Development Index (HDI) and lifestyle risk factors with eyelid skin cancers in Iran.
This ecological study analyzed the data collected from the Iranian National Population-based Cancer Registry (2005-2016). The data on provincial-level eyelid skin cancer risk factors were obtained from national sources. The association between provincial HDI and lifestyle risk factors with the prevalence of eyelid skin cancers was assessed.
The mean 12-year age-standardized incidence rate (ASIR) of eyelid skin cancers was 16.22 per 100,000 (9,104 cases). The overall ASIR showed an upward trend with an estimated annual average increase of 0.006 per year. There were positive correlations between the prevalence of overall eyelid skin cancers and provincial HDI, smoking, and obesity (r = 0.32, 0.42, and 0.37, respectively). In multivariate analysis, obesity/overweight remained a positive predictor for high prevalence of total eyelid skin cancers (OR = 1.97, 95%CI = 1.08-3.58, P = 0.026), carcinoma (2.10, 1.15-3.83, P = 0.015), and basal cell carcinoma (1.48, 0.99-2.20, P = 0.054).
An increasing trend in ASIR of eyelid skin cancers was observed in more than a decade in Iran which was positively associated with provincial HDI and prevalence of obesity. The findings of the study highlight the importance of promotional programs for preventing obesity/overweight and appropriate allocation of screening facilities based on the HDI level.
眼睑皮肤癌是最常见的眼部恶性肿瘤。本研究旨在评估人类发展指数（HDI）和生活方式危险因素与伊朗眼睑皮肤癌的关联。
本生态研究分析了伊朗国家基于人群的癌症登记处（2005-2016 年）收集的数据。省级眼睑皮肤癌危险因素数据来自国家来源。评估了省级人类发展指数和生活方式危险因素与眼睑皮肤癌患病率之间的关联。
12 年来眼睑皮肤癌的平均年龄标准化发病率（ASIR）为 16.22/10 万（9104 例）。总体 ASIR 呈上升趋势，估计每年平均增长 0.006/年。整体眼睑皮肤癌的患病率与省级人类发展指数、吸烟和肥胖呈正相关（r=0.32、0.42 和 0.37）。在多变量分析中，肥胖/超重仍然是总眼睑皮肤癌高发的正预测因子（OR=1.97，95%CI=1.08-3.58，P=0.026）、癌（2.10，1.15-3.83，P=0.015）和基底细胞癌（1.48，0.99-2.20，P=0.054）。
在伊朗，超过 10 年来，ASIR 呈上升趋势，与省级人类发展指数和肥胖患病率呈正相关。该研究结果强调了预防肥胖/超重和根据人类发展指数水平适当分配筛查设施的宣传计划的重要性。
