Lee Chia-Lin, Huang Po-Ching, Hsieh Pei-Wen, Hwang Tsong-Long, Hou Yu-Yi, Chang Fang-Rong, Wu Yang-Chang
Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung, Taiwan.
Planta Med. 2008 Aug;74(10):1276-9. doi: 10.1055/s-2008-1081295. Epub 2008 Jul 11.
The dried seeds of XANTHIUM STRUMARIUM (Asteraceae) are used after thorough stir-frying as an ingredient in traditional Chinese medicines for relieving allergy. Two new compounds, xanthialdehyde ( 2) and (-)-xanthienopyran ( 7), as well as 26 known compounds were isolated in the present study. The structures of the isolates were elucidated by spectroscopic methods. Among them, compound 7 exhibited significant selective inhibition of superoxide anion generation by human neutrophils induced by formyl- L-methionyl- L-leucyl- L-phenylalanine, with an IC50 value of 1.72 microg/mL.
苍耳（菊科）干燥成熟带总苞的果实经炒后作为中药成分用于抗过敏。本研究从苍耳中分离得到两个新化合物，苍耳醛（2）和（-）-苍耳噻喃（7），以及26个已知化合物。通过光谱方法鉴定了分离物的结构。其中，化合物7对甲酰- L-甲硫氨酰-L-亮氨酰-L-苯丙氨酸诱导的人中性粒细胞超氧阴离子生成具有显著的选择性抑制作用，IC50值为1.72 μg/mL。
