Genaro Patricia de Souza, Pereira Giselle Adriana de Paiva, Pinheiro Marcelo de Medeiros, Szejnfeld Vera Lúcia, Martini Lígia Araújo
Department of Nutrition, School of Public Health, University of São Paulo, Avenida Dr Arnaldo 715, São Paulo-SP, Brazil.
Int J Vitam Nutr Res. 2007 Nov;77(6):376-81. doi: 10.1024/0300-9831.77.6.376.
Vitamin D is essential for maintaining calcium homeostasis and optimizing bone health. Its inadequacy is related to many factors including dietary intake. The aim of the present study was to evaluate serum 25(OH)D and its relationship with nutrient intakes in postmenopausal Brazilian women with osteoporosis. This cross-sectional study comprised 45 free-living and assisted elderly at São Paulo Hospital. Three-day dietary records were used to assess dietary intakes. Bone mineral density was measured with a dual-energy X-ray absorptiometer (DXA). Blood and urine sample were collected for analysis of biochemical markers of bone and mineral metabolism. Insufficiency of vitamin D was observed in 24.4% of the women and optimal levels (> or = 50 nmol/L) were observed in 75.6%. Parathyroid hormone was above the reference range in 51% of the participants. The mean calcium (724 mg/day) and vitamin D (4.2 microg/day) intakes were lower than the value proposed by The Food and Nutrition Board and sodium intake was more than two-fold above the recommendation. Higher levels of serum 25(OH)D were inversely associated with sodium intake. Dietary strategies to improve serum vitamin D must focus on increasing vitamin D intake and should take a reduction of sodium intake into consideration.
维生素D对于维持钙稳态和优化骨骼健康至关重要。其不足与包括饮食摄入在内的许多因素有关。本研究的目的是评估巴西绝经后骨质疏松症女性的血清25(OH)D及其与营养素摄入量的关系。这项横断面研究纳入了圣保罗医院45名独立生活和接受照料的老年人。采用3天饮食记录来评估饮食摄入量。使用双能X线吸收仪(DXA)测量骨密度。采集血液和尿液样本以分析骨和矿物质代谢的生化标志物。24.4%的女性存在维生素D不足,75.6%的女性维生素D水平处于最佳范围(≥50 nmol/L)。51%的参与者甲状旁腺激素高于参考范围。钙的平均摄入量(724毫克/天)和维生素D的平均摄入量(4.2微克/天)低于食品营养委员会建议的值,而钠摄入量比建议值高出两倍多。血清25(OH)D水平较高与钠摄入量呈负相关。改善血清维生素D的饮食策略必须侧重于增加维生素D摄入量,并且应考虑减少钠摄入量。