Jensen E M, Korol W, Dittmar S L, Medrek T J
The John L. Smith Memorial for Cancer Research, Chas. Pfizer & Co., Inc., Maywood, New Jersey 07607, USA.
J Natl Cancer Inst. 1967 Oct;39(4):745-54.
Seven continuous cell cultures were established from 45 lymphoid tissue specimens from 43 cancer patients. All cultures were free-floating and appeared to be primarily lymphoblasts. Electron microscopic examination revealed herpesvirus-like particles in all the established cell lines and in one cell line that was maintained for only 1 month. The particles appeared identical to those observed in Burkitt's lymphoma and other lymphoma and leukemia cultures. In one instance virus particles were observed in the original tissue specimen before cultivation. The virus particles were not infectious for several cell lines known to be susceptible to herpes simplex virus and other members of this group.
从43名癌症患者的45份淋巴组织标本中建立了7个连续细胞培养物。所有培养物均为悬浮生长，主要由淋巴母细胞组成。电子显微镜检查发现，在所有已建立的细胞系以及一个仅维持了1个月的细胞系中均存在疱疹病毒样颗粒。这些颗粒与在伯基特淋巴瘤以及其他淋巴瘤和白血病培养物中观察到的颗粒相同。在一个实例中，在培养前的原始组织标本中观察到了病毒颗粒。这些病毒颗粒对几种已知对单纯疱疹病毒和该病毒组其他成员敏感的细胞系没有感染性。
