Lemos Carolina, Castro Maria-José, Barros José, Sequeiros Jorge, Pereira-Monteiro José, Mendonça Denisa, Sousa Alda
UnIGENe, Instituto Biologia Molecular Celular, Universidade do Porto, Rua do Campo Alegre, Porto, Portugal.
Headache. 2009 Mar;49(3):404-11. doi: 10.1111/j.1526-4610.2008.01177.x. Epub 2008 Jul 1.
Our aim was to evaluate familial aggregation of migraine in a large group of Portuguese families, and to assess if familial aggregation differs between MA and MO.
Familial aggregation was evaluated by estimating relative risk (RR) of migraine in 143 first-degree relatives of 50 probands with MA, in 196 first-degree relatives of 94 probands with MO and also in proband's spouses. Probands were enrolled in the study from a clinical sample and a population sample was used as reference.
A significantly increased risk of migraine was found in both first-degree relatives of MO probands (RR = 3.7; 95% CI: 3.2-4.3) and of MA probands (RR = 3.6; 95% CI: 3.1-4.3), comparatively to the general population. Risk for spouses was not increased. First-degree relatives of MA probands and MO probands had a significantly increased risk of both MA and MO compared to the general population. In the group of MA probands, RR of MA in first-degree relatives reached a significant 4-fold increase when compared with RR of MO (RR(MA|MA) = 12.2, 95%CI: 7.7-19.5; RR(MO|MA) = 3.1, 95%CI: 2.5-3.8), while, in the group of MO probands, RR of MA was not significantly increased when compared with RR of MO (RR(MA|MO) = 5.3, 95%CI: 3.1-9.2; RR(MO|MO) = 4.0, 95%CI: 3.5-4.7).
The present study focus on familial aggregation of migraine in a Portuguese population. Our results demonstrate a substantial familial risk of migraine with evidence of both common and specific etiologic mechanisms for either migraine subtypes.
我们的目的是评估一大群葡萄牙家庭中偏头痛的家族聚集性，并评估偏头痛性头痛（MA）和无先兆偏头痛（MO）之间的家族聚集性是否存在差异。
通过估计50例MA先证者的143名一级亲属、94例MO先证者的196名一级亲属以及先证者配偶中偏头痛的相对风险（RR）来评估家族聚集性。先证者从临床样本中纳入研究，并将人群样本用作对照。
与普通人群相比，MO先证者的一级亲属（RR = 3.7；95%CI：3.2 - 4.3）和MA先证者的一级亲属（RR = 3.6；95%CI：3.1 - 4.3）中偏头痛风险均显著增加。配偶的风险未增加。与普通人群相比，MA先证者和MO先证者的一级亲属患MA和MO的风险均显著增加。在MA先证者组中，一级亲属患MA的RR与患MO的RR相比显著增加了4倍（RR(MA|MA) = 12.2，95%CI：7.7 - 19.5；RR(MO|MA) = 3.1，95%CI：2.5 - 3.8），而在MO先证者组中，MA的RR与MO的RR相比未显著增加（RR(MA|MO) = 5.3，95%CI：3.1 - 9.2；RR(MO|MO) = 4.0，95%CI：3.5 - 4.7）。
本研究聚焦于葡萄牙人群中偏头痛的家族聚集性。我们的结果表明偏头痛存在显著的家族风险，且两种偏头痛亚型均有常见和特定病因机制的证据。
