Russell M B, Iselius L, Olesen J
Department of Neurology, Glostrup Hospital, University of Copenhagen, Denmark.
Cephalalgia. 1996 Aug;16(5):305-9. doi: 10.1046/j.1468-2982.1996.1605305.x.
The familial occurrence and mode of inheritance were analysed in families with migraine without aura (MO) and migraine with aura (MA). The probands were found among 4000 persons from the general population. All persons with MA were included as probands, and an equivalent number of probands with MO was selected as a random sample among those with MO. Spouses and first-degree relatives were blindly interviewed. All interviews were performed by one neurological research fellow. The distinct familial patterns indicate that MO and MA have a different aetiology. Compared with the general population, the first-degree relatives of probands with MO had a 1.9-fold increased risk of MO while spouses had a 1.5-fold increased risk of MO, indicating that both genetic and environmental factors are important in MO. The first-degree relatives of probands with MA had a four-fold increased risk of MA while spouses had no increased risk of MA, indicating that MA is determined largely by genetic factors. The complex segregation analysis indicated that both MO and MA have multifactorial inheritance without generational difference.
对无先兆偏头痛（MO）和有先兆偏头痛（MA）患者的家族发病情况及遗传模式进行了分析。先证者来自4000名普通人群。所有MA患者均被纳入先证者，同时从MO患者中随机抽取等量数量的先证者。对配偶和一级亲属进行了盲法访谈。所有访谈均由一名神经科研究员进行。不同的家族模式表明，MO和MA有不同的病因。与普通人群相比，MO先证者的一级亲属患MO的风险增加了1.9倍，而配偶患MO的风险增加了1.5倍，这表明遗传和环境因素在MO中都很重要。MA先证者的一级亲属患MA的风险增加了四倍，而配偶患MA的风险没有增加，这表明MA在很大程度上由遗传因素决定。复杂分离分析表明，MO和MA均具有多因素遗传且无代际差异。
