Department of Neurology, Tri-Service General Hospital, National Defense Medical Center, Neihu, Taipei, Taiwan.
Department of Psychiatry, Beitou Branch, Tri-Service General Hospital, National Defense Medical Center, Beitou, Taipei, Taiwan.
PLoS One. 2020 Feb 5;15(2):e0228284. doi: 10.1371/journal.pone.0228284. eCollection 2020.
The relationships between family history, sex, age at onset, and migraine occurrence have been documented. However, the associations between these factors across different sexes and subgroups of patients have yet to be elucidated. This study evaluated the association between family history and migraine in male and female patients experiencing episodic and chronic migraine with and without aura.
This cross-sectional, case-control study included 299 headache-free controls and 885 patients receiving outpatient treatment for migraine. Participants were classified into episodic (1-14 days/month) and chronic (≥15 days/month) migraine groups.
Positive family history was significantly more frequently observed in the episodic group than in the chronic group (49.5% vs. 26%; P < 0.001) in male patients, particularly in male patients without aura (50.3% vs. 21.9%; P = 0.003); it was less frequently observed (58.7% vs. 73.7%; P = 0.048) in female patients with aura. Family history was correlated with an earlier age at onset (20.7 years vs. 22.8 years; P = 0.002), particularly in patients without aura (21 years vs. 23.7 years; P = 0.002), who were women (20.9 years vs. 23.9 years; P = 0.002).
Different patterns of association between family history and migraine can be observed between men and women. A positive family history of migraine is correlated with an earlier age at onset, particularly among female patients without aura.
家族史、性别、发病年龄与偏头痛发生之间的关系已有记载。然而，这些因素在不同性别和患者亚组之间的关联尚未阐明。本研究评估了有或无先兆的发作性和慢性偏头痛男性和女性患者中家族史与偏头痛之间的关系。
这是一项横断面、病例对照研究，纳入了 299 名无头痛的对照者和 885 名接受偏头痛门诊治疗的患者。参与者分为发作性（1-14 天/月）和慢性（≥15 天/月）偏头痛组。
在男性患者中，阳性家族史在发作性组中比在慢性组中更为常见（49.5%比 26%；P<0.001），特别是在无先兆的男性患者中（50.3%比 21.9%；P=0.003）；在有先兆的女性患者中，阳性家族史较少见（58.7%比 73.7%；P=0.048）。家族史与发病年龄较早相关（20.7 岁比 22.8 岁；P=0.002），尤其是在无先兆的患者中（21 岁比 23.7 岁；P=0.002），且这些患者为女性（20.9 岁比 23.9 岁；P=0.002）。
可以观察到家族史与偏头痛之间的关联在男性和女性之间存在不同的模式。偏头痛的阳性家族史与发病年龄较早相关，尤其是在无先兆的女性患者中。
