Albury Cassie L, Stuart Shani, Haupt Larisa M, Griffiths Lyn R
Genomics Research Centre, Institute for Biomedical Health and Innovation, Queensland University of Technology, Brisbane, QLD, 4059, Australia.
Mol Genet Genomics. 2017 Aug;292(4):729-739. doi: 10.1007/s00438-017-1317-1. Epub 2017 Apr 7.
Migraine is a common neurological disorder that affects approximately 12-20% of the general adult population. Migraine pathogenesis is complex and not wholly understood. Molecular genetic investigations, imaging and biochemical studies, have unveiled a number of interconnected neurological pathways which seem to have a cause and effect component integral to its cause. Much weight of migraine attack initiation can be placed on the initial trigger and the pathways involved in its neuronal counter reaction. Ion channels play a large role in the generation, portrayal and mitigation of the brains response to external triggers. Several genetic studies have identified and implicated a number of ion channelopathy genes which may contribute to this generalised process. This review will focus on the genetics of migraine with particular emphasis placed on the potentially important role genes HEPH (responsible for iron transport and homeostasis) and KCNK18 (important for the transport and homeostasis of potassium) play in migraine cause.
偏头痛是一种常见的神经系统疾病，影响着约12%至20%的成年普通人群。偏头痛的发病机制复杂，尚未完全明确。分子遗传学研究、影像学和生物化学研究揭示了一些相互关联的神经通路，这些通路似乎在其病因中具有因果关系成分。偏头痛发作的起始很大程度上取决于初始触发因素及其神经元反应所涉及的通路。离子通道在大脑对外部触发因素的反应的产生、表现和缓解中起着重要作用。多项遗传学研究已经确定并牵连了一些可能导致这一普遍过程的离子通道病基因。本综述将聚焦于偏头痛的遗传学，特别强调基因HEPH（负责铁运输和体内平衡）和KCNK18（对钾的运输和体内平衡很重要）在偏头痛病因中可能发挥的重要作用。
