Johnson Thomas V, Fan Shan, Camras Carl B, Toris Carol B
Department of Ophthalmology, Universityof Nebraska Medical Center, Omaha, NE 68198-5840, USA.
Arch Ophthalmol. 2008 Jul;126(7):914-20. doi: 10.1001/archopht.126.7.914.
To examine how aqueous humor dynamics are affected by exfoliation syndrome (XFS) with or without elevated intraocular pressure (IOP).
Eighty participants were divided into 4 groups: (1) those with XFS and ocular normotension (n = 25), (2) controls with ocular normotension without XFS, age-matched to group 1 (n = 25), (3) those with XFS and ocular hypertension (n = 15), and (4) controls with ocular hypertension without XFS, age-matched to group 3 (n = 15). Following washout of glaucoma medications, assessments were made of IOP, episcleral venous pressure, aqueous flow, outflow facility, and uveoscleral outflow. Differences were analyzed by group mean comparisons and linear regression analyses.
Uveoscleral outflow was significantly decreased in individuals with XFS compared with age-matched controls and was independent of IOP. Patients with ocular hypertension (with or without XFS) exhibited decreased outflow facility compared with those with ocular normotension (with or without XFS). Aqueous flow was not affected by the level of IOP or the presence of XFS.
Exfoliation syndrome in normotensive and hypertensive eyes is associated with a decrease in uveoscleral outflow, whereas in hypertensive but not normotensive eyes, it is associated with reduced outflow facility.
研究剥脱综合征（XFS）伴或不伴眼压（IOP）升高时房水动力学如何受到影响。
80名参与者被分为4组：（1）患有XFS且眼压正常者（n = 25），（2）与第1组年龄匹配的眼压正常且无XFS的对照组（n = 25），（3）患有XFS且眼压高者（n = 15），以及（4）与第3组年龄匹配的眼压高且无XFS的对照组（n = 15）。停用青光眼药物后，对眼压、巩膜静脉压、房水流量、流出易度和葡萄膜巩膜流出量进行评估。通过组均值比较和线性回归分析来分析差异。
与年龄匹配的对照组相比，XFS患者的葡萄膜巩膜流出量显著降低，且与眼压无关。与眼压正常者（伴或不伴XFS）相比，眼压高的患者（伴或不伴XFS）流出易度降低。房水流量不受眼压水平或XFS存在与否的影响。
眼压正常和眼压高的眼中的剥脱综合征均与葡萄膜巩膜流出量减少有关，而在眼压高但眼压正常的眼中，它与流出易度降低有关。
