Tada Yoshifumi, Fukuoka Mami, Mitamura Mio, Koarada Shuichi, Suematsu Rie, Inoue Hisako, Ohta Akihide, Nagasawa Kohei
Department of Internal Medicine, Saga Medical School, Saga, Japan.
Am J Med Sci. 2008 Jul;336(1):77-80. doi: 10.1097/MAJ.0b013e318159e0b4.
Four cases of nocardiosis in patients with adult-onset Still disease and vasculitis syndrome are presented. Three patients developed lung abscesses and 1 case developed a brain abscess. All were treated with high-dose corticosteroids, and 3 were given cyclosporine when they developed nocardiosis. All patients were successfully treated with antibiotics; cyclosporine was discontinued in 2 cases. These cases indicate that systemic nocardiosis can develop in patients with various rheumatologic diseases who are treated with corticosteroid and immunosuppressive drugs such as cyclosporine.
本文报告了4例成人斯蒂尔病和血管炎综合征患者发生诺卡菌病的病例。3例患者发生肺脓肿，1例发生脑脓肿。所有患者均接受大剂量糖皮质激素治疗，3例在发生诺卡菌病时给予环孢素治疗。所有患者均通过抗生素成功治愈；2例停用了环孢素。这些病例表明，接受糖皮质激素和环孢素等免疫抑制药物治疗的各种风湿性疾病患者可能发生系统性诺卡菌病。
