Mintz Emily M, George Dornechia E, Hsu Sylvia
Dermatol Online J. 2008 Mar 15;14(3):19.
Silver sulfadiazine (SSD) cream, most known for its use in the treatment of extensive burn wounds, is commonly used in the management of erosions in bullous disorders. The beneficial antibacterial effect of SSD use is not without risk, as silver toxicity has been well documented in burn patients. Renal insufficiency accelerates silver accumulation and thus toxicity. Data on silver toxicity in patients with primary blistering disorders is scarce; however the literature regarding silver toxicity in burn patients may be applicable to patients with bullous diseases. Hence we recommend that clinicians exercise caution when prescribing protracted wound care with SSD for blistering disorders.
磺胺嘧啶银（SSD）乳膏最为人所知的用途是治疗大面积烧伤创面，它也常用于治疗大疱性疾病的糜烂。使用SSD的有益抗菌效果并非没有风险，因为银中毒在烧伤患者中已有充分记录。肾功能不全加速银的蓄积，进而导致中毒。关于原发性水疱性疾病患者银中毒的数据很少；然而，关于烧伤患者银中毒的文献可能适用于大疱性疾病患者。因此，我们建议临床医生在为水疱性疾病患者长期开具SSD伤口护理处方时要谨慎。
