Prodoehl Janey, Corcos Daniel M, Leurgans Sue, Comella Cynthia L, Weis-McNulty Annette, MacKinnon Colum D
Department of Kinesiology and Nutrition, University of Illinois, Chicago, Chicago, IL 60612, USA.
J Mot Behav. 2008 Jul;40(4):301-13. doi: 10.3200/JMBR.40.4.301-314.
The authors examined the relationship between movement velocity and distance and the associated muscle activation patterns in 18 individuals with focal hand dystonia (FHD) compared with a control group of 18 individuals with no known neuromuscular condition. Participants performed targeted voluntary wrist and elbow flexion movements as fast as possible across 5 movement distances. Individuals with FHD were slower than controls across all distances, and this difference was accentuated for longer movements. Muscle activation patterns were triphasic in the majority of individuals with FHD, and muscle activation scaled with distance in a similar manner to controls. Cocontraction did not explain movement slowing in individuals with dystonia, but there was a trend toward underactivation of the 1st agonist burst in the dystonic group. The authors concluded that slowness is a consistent feature of voluntary movement in FHD and is present even in the absence of dystonic posturing. Underactivation of the 1st agonist burst appears to be the most likely reason to explain slowing.
作者研究了18例局限性手部肌张力障碍（FHD）患者与18例无已知神经肌肉疾病的对照组之间运动速度和距离以及相关肌肉激活模式的关系。参与者在5个运动距离上尽可能快地进行有目标的自愿手腕和肘部屈曲运动。FHD患者在所有距离上都比对照组慢，并且这种差异在更长的运动中更加明显。大多数FHD患者的肌肉激活模式是三相的，并且肌肉激活随距离的变化方式与对照组相似。协同收缩并不能解释肌张力障碍患者的运动减慢，但在肌张力障碍组中，首次主动肌爆发存在激活不足的趋势。作者得出结论，运动缓慢是FHD患者自主运动的一个一致特征，即使在没有肌张力障碍姿势的情况下也存在。首次主动肌爆发的激活不足似乎是解释运动减慢的最可能原因。
