Robinson S L, Rowbotham D J, Smith G
University Department of Anaesthesia, Leicester Royal Infirmary.
Anaesthesia. 1991 Jul;46(7):538-40. doi: 10.1111/j.1365-2044.1991.tb09650.x.
The dose requirements and side effects of morphine were compared with those of diamorphine administered by patient-controlled analgesia in 40 patients following elective total hip replacement. Patients were allocated randomly to receive in a double-blind manner either morphine or diamorphine for postoperative pain relief. There were no significant differences between the two groups with regard to postoperative sedation, nausea, well-being, pain relief and requirements for antiemetic drugs. The dose requirement for diamorphine was approximately 50% of that for morphine.
对40例行择期全髋关节置换术的患者，比较了吗啡与二醋吗啡通过患者自控镇痛给药时的剂量需求及副作用。患者被随机分配，以双盲方式接受吗啡或二醋吗啡用于术后止痛。两组在术后镇静、恶心、舒适度、疼痛缓解及止吐药物需求方面无显著差异。二醋吗啡的剂量需求约为吗啡的50%。
